AMINO PROPYL TRIETHOXY SILANE

Amino propyl triethoxy silane  is an aminosilane frequently used in the process of silanization, the functionalization of surfaces with alkoxysilane molecules. 
Amino propyl triethoxy silane  can also be used for covalent attaching of organic films to metal oxides such as silica and titania.
Amino propyl triethoxy silane is a surface treatment used to chemically couple various ligands to glass or silica surfaces such as glass slides. 

CAS Number : 919-30-2
EC  Number : 213-048-4
Molecular Formula :    C9H23NO3Si
Molecular Weight  :     221.37

Use with PDMS of amino propyl triethoxy silane 
Amino propyl triethoxy silane  can be used to covalently bond thermoplastics to poly(dimethylsiloxane) (PDMS).
Thermoplastics are treated with oxygen plasma to functionalize surface molecules, and subsequently coated with an aqueous 1% by volume amino propyl triethoxy silane  solution. 
PDMS is treated with oxygen plasma and placed in contact with the functionalized thermoplastic surface. 
A stable, covalent bond forms within 2 minutes.

Silsesquioxane synthesis of amino propyl triethoxy silane 
Amino propyl triethoxy silane  can be obtained in a one step hydrolytic condensation using APTES and hydrochloric or trifluoromethanesulfonic acid (CF3SO3H).

Use with cell cultures of amino propyl triethoxy silane 
Amino propyl triethoxy silane -functionalized surfaces have been shown to be nontoxic to embryonic rat cardiomyocytes in vitro.
Further experimentation is needed to evaluate toxicity to other cell types in extended culture.

Toxicity of amino propyl triethoxy silane
Amino propyl triethoxy silane is a toxic compound with an MSDS health hazard score of 3.
Amino propyl triethoxy silane fumes are destructive to the mucous membranes and the upper respiratory tract, and should be used in a fume hood with gloves. 
If a fume hood is not available, a face shield and full face respirator must be implemented. 
The target organs of amino propyl triethoxy silane are nerves, liver and kidney.

Use and Manufacturing of amino propyl triethoxy silane
Used to size glass fibers for making laminates and to make non-thrombogenic dental and orthopedic materials; [HSDB] Used as coupling agent and adhesion promoter in fiberglass, adhesives, sealants, foundry resins, and coatings
Used as coupling agents and adhesion promoters, aminosilanes are intentionally converted by hydrolysis to the trisilanols, which then bond molecularly to inorganic substrates
The commercial uses of this material are numerous and include various applications as coupling agents and adhesion promoters in fiberglass, adhesives and sealants, foundry resins, and in pre-treatment for coatings. A small percentage of this material may be found in sealants and coatings.

Industry Uses of amino propyl triethoxy silane
Adhesion/cohesion promoter
Adhesives and sealant chemicals
Intermediate
Intermediates
Paint additives and coating additives not described by other categories
Plating agents and surface treating agents

Consumer Uses of amino propyl triethoxy silane
Adhesives and sealant chemicals

Household Products of amino propyl triethoxy silane
Household & Commercial/Institutional Products
Information on 5 consumer products that contain 3-Aminopropyltriethoxysilane in the following categories is provided:
Auto Products
Home Maintenance

Features of amino propyl triethoxy silane:

Crosslinking agents such as BS3, EDC and Sulfo-SMCC can be used to immobilize proteins, peptides, modified DNA, etc., to the treated surface
Coats certain plastic surfaces noncovalently to create a reactive film
Chemically adheres tissue sections to glass slides for immunohistochemistry

Amino propyl triethoxy silane is a surface treatment used to chemically couple various ligands to glass or silica surfaces such as glass slides. 
Amino propyl triethoxy silane is first coupled to glass or silica through the silane. 
Compounds of interest are then coupled to the newly added amino groups directly, or additional chemistries are applied using the amino function prior to coupling.

Application of amino propyl triethoxy silane:

1. Composite Material: 
Amino propyl triethoxy silane is widely used in composite materials to improve the compatibility of inorganic filler and polymer in composite materials. 
The mechanical properties, such as tensile and bending resistance, as well as thermal properties, electrical properties and water resistance, etc. of the composites are significantly improved. 
Especially suitable for all kinds of glass fiber reinforced thermoplastic and thermosetting resins.

2. Resin Modified: 
Amino propyl triethoxy silane can be used as the raw material of a new generation of amino modified silicone oil and a variety of silicone super soft finishing agents.

3. Adhesive: 
Amino propyl triethoxy silane used in nitrile - phenolic structural adhesive, polyethylene butanaldehyde - phenolic adhesive, polyurethane adhesive hot melt adhesive, add 1% of the solid content or less, can make the bond strength increased by 60% to 100%. 
Add this sealant to polyurethane sealant and plastic-melt sealant to obtain long-term adhesion to glass, masonry, metal and other substrates, and have excellent stability and high elongation to the climate.

4. Coating/Ink: 
Amino propyl triethoxy silane can be used in coating, ink as an adhesive enhancer to improve adhesion, reduce curing temperature, improve weather resistance, etc.

5. Casting Resin Industry: 
Amino propyl triethoxy silane can be used in the casting industry to reduce the amount of resin in silica sand, improve the strength of mold sand (about 30%) and reduce gas production.

6. Magnetic Material: 
Amino propyl triethoxy silane used in magnetic materials can improve the dispersion and adhesion of the plastic magnetic and rubber magnetic particles in organic compound, so that the magnetic particles have a higher orientation. 
So that amino propyl triethoxy silane can obtain better magnetic properties, improve the mechanical strength and weather resistance of magnetic materials, also easy to dry and easy to process.

Amino propyl triethoxy silane is used as an amino-silane which is mainly used as a dispersant. 
Amino propyl triethoxy silane attaches an amino group to the functional silane for bio-conjugation.

Application of amino propyl triethoxy silane
Forms aminopropyl derivative of glass, an adsorbent for affinity chromatography. 
Used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures.
Recently amino propyl triethoxy silane has been used to prepare dye-doped silica nanoparticles with minimal aggregation and minimal nonspecific binding with biomolecules.

Self-assembled monolayer (SAM) of amino propyl triethoxy silane can be used to improve the adhesion of graphene flakes and SiO2 to enable better contact with the metal electrodes. 
These electrodes may be used as electro-responsive tools for bio-sensing applications.
Amino propyl triethoxy silane can be used to functionalize silane diazirine for fiber optic biosensor application.
Hollow microcarriers (HMCs) can be surface modified with amino propyl triethoxy silane which may be used for regenerative medicines and recombinant cells in biopharmaceutical industries.
Used in a preparation of a series of tenary composite films of polyimide/SiO/polydiphenylsiloxane with good optical transparency.

Amino propyl triethoxy silane is useful in the formation of aminopropyl derivative of glass. 
Amino propyl triethoxy silane acts as an adsorbent for affinity chromatography. 
Amino propyl triethoxy silane is used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures. 
In addition, amino propyl triethoxy silane is used as adhesives and sealant chemicals, paint additives and coating additives. 
Further, amino propyl triethoxy silane is used as a silylation reagent for coating glass and silica surfaces and to crosslink and immobilize proteins and other molecules.

Applications of amino propyl triethoxy silane
Amino propyl triethoxy silane is useful in the formation of aminopropyl derivative of glass. 
Amino propyl triethoxy silane acts as an adsorbent for affinity chromatography. 
Amino propyl triethoxy silane is used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures. 
In addition,amino propyl triethoxy silane is used as adhesives and sealant chemicals, paint additives and coating additives. 
Further, amino propyl triethoxy silane is used as a silylation reagent for coating glass and silica surfaces and to crosslink and immobilize proteins and other molecules.

FIRST AID MEASURES of amino propyl triethoxy silane

General advice
Consult a physician. 
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area.

If inhaled
If breathed in, move person into fresh air. 
If not breathing, give artificial respiration. 
Consult a physician.

In case of skin contact
Take off contaminated clothing and shoes immediately. 
Wash off with soap and plenty of water. 
Consult a physician.

In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed
Do NOT induce vomiting. 
Never give anything by mouth to an unconscious person. 
Rinse mouth with water. 
Consult a physician.

Substance identity

EC / List no.: 213-048-4
CAS no.: 919-30-2
Mol. formula: C9H23NO3Si

Hazard classification & labelling of Amino propyl triethoxy silane 
Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, amino propyl triethoxy silane  causes severe skin burns and eye damage and is harmful if swallowed.
Additionally, the classification provided by companies to ECHA in REACH registrations identifies that amino propyl triethoxy silane  causes serious eye damage and may cause an allergic skin reaction.

About Amino propyl triethoxy silane 
Amino propyl triethoxy silane  is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Amino propyl triethoxy silane  is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses of Amino propyl triethoxy silane
Amino propyl triethoxy silane is used in the following products: adhesives and sealants and coating products.
Other release to the environment of amino propyl triethoxy silane is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Article service life of Amino propyl triethoxy silane
Release to the environment of amino propyl triethoxy silane can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). 
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers of Amino propyl triethoxy silane
Amino propyl triethoxy silane is used in the following products: adhesives and sealants, coating products and laboratory chemicals.
Amino propyl triethoxy silane is used in the following areas: building & construction work and formulation of mixtures and/or re-packaging.
Amino propyl triethoxy silane is used for the manufacture of: machinery and vehicles, furniture, plastic products, mineral products (e.g. plasters, cement), wood and wood products, fabricated metal products, electrical, electronic and optical equipment, textile, leather or fur and pulp, paper and paper products.
Release to the environment of Amino propyl triethoxy silane can occur from industrial use: formulation of mixtures.
Other release to the environment of Amino propyl triethoxy silane is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Formulation or re-packing of Amino propyl triethoxy silane
Amino propyl triethoxy silane is used in the following products: coating products, adhesives and sealants, non-metal-surface treatment products, polymers and oil and gas exploration or production products.
Release to the environment of Amino propyl triethoxy silane can occur from industrial use: formulation of mixtures, in the production of articles and formulation in materials.
Other release to the environment of Amino propyl triethoxy silane is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Uses at industrial sites of Amino propyl triethoxy silane
Amino propyl triethoxy silane is used in the following products: oil and gas exploration or production products, coating products, non-metal-surface treatment products, adhesives and sealants and laboratory chemicals.
Amino propyl triethoxy silane has an industrial use resulting in manufacture of another substance (use of intermediates).
Amino propyl triethoxy silane is used in the following areas: mining and building & construction work.
Amino propyl triethoxy silane is used for the manufacture of: chemicals, mineral products (e.g. plasters, cement), machinery and vehicles and plastic products.
Release to the environment of Amino propyl triethoxy silane can occur from industrial use: in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, as processing aid, as processing aid, of substances in closed systems with minimal release, formulation of mixtures and in processing aids at industrial sites.

Manufacture of Amino propyl triethoxy silane
Release to the environment of Amino propyl triethoxy silane can occur from industrial use: manufacturing of the substance, for thermoplastic manufacture and as an intermediate step in further manufacturing of another substance (use of intermediates).

Synonyms:
(3-Aminopropyl)triethoxysilane
(gamma-Aminopropyl)triethoxysilane
1-Propanamine, 3-(triethoxysilyl)-
3-(Triethoxysilyl)-1-propanamine
3-(Triethoxysilyl)propylamine
3-aminopropyltriethoxysilane
3-Aminopropyltriethoxysilane
919-30-2
Nuca 1100
Propylamine, 3-(triethoxysilyl)- (8CI)
Silane 1100
Silane amg-9
Silane, (3-aminopropyl)triethoxy-
Silane, gamma-aminopropyltriethoxy-
Silicone A-1100
Triethoxy(3-aminopropyl)silane
Uc-A 1100
3-aminopropyltriethoxysilane
AGM-9
Amino-propyl-triethoxysilane
APTES
(3-aminopropyl)tri(etoxy)silán (sk)
(3-aminopropylo)trietoksysilan (pl)
3-(trietossisilil)-1-propanamina (it)
3-aminopropiltrietoksisilan (hr)
3-aminopropiltrietoksisilan (sl)
3-aminopropiltrietoksisilanas (lt)
3-aminopropiltrietoksisilāns (lv)
3-aminopropiltrietoxisilan (ro)
3-aminopropiltrietoxisilano (es)
3-aminopropiltrietoxiszilán (hu)
3-aminopropiltrietóxissilano (pt)
3-aminopropyltriethoxysilaan (nl)
3-aminopropyltriethoxysilan (cs)
3-aminopropyltriethoxysilan (da)
3-Aminopropyltriethoxysilan (de)
3-aminopropyltrietoksysilan (no)
3-aminopropyltrietoxisilan (sv)
3-aminopropyltriéthoxysilane (fr)
3-Aminopropyylitrietoksisilaani (fi)
3-aminopropüültrietoksüsilaan (et)
3-amminopropiltrietossisilano (it)
3-αμινοπροπυλοτριαιθοξυσιλάνιο (el)
3-аминопропилтриетоксисилан (bg)
1-Propanamine, 3-(triethoxysilyl)-
(3-aminopropyl)triethoxysilane
, Registration dossier, Other
1-Propanamine, 3-(triethoxysilyl)-
1-Propylamine, 3-(triethoxysilyl)-
3-(Triethoxysilyl) propylamine
3-(Triethoxysilyl)-1-propanamine
3-(Triethoxysilyl)-propylamin
3-(Triethoxysilyl)propan-1-amine
3-(triethoxysilyl)propan-1-amine
3-(triethoxysilyl)propan-1-amine, partialy polymerized
3-aminopropyl-triethoxysilane
3-Aminopropyltriethoxysilan
3-AMINOPROPYLTRIETHOXYSILANE
3-Aminopropyltriethoxysilane
3-aminopropyltriethoxysilane
3-aminopropyltriethoxysilane
3-Triethoxysilylpropan-1-amine
3-triethoxysilylpropan-1-amine
3-Triethoxysilylpropylamine
aminopropylalkoxysilane
Aminopropyltriethoxysilane
Aminopropyltriethoxysilane
aminopropyltriethoxysilane
aminosilane
APTES, APTS
Damsil 1350
gamma-Aminopropyltriethoxy silane
gamma-Aminopropyltriethoxysilane
silane
triethoxysilylpropan-1-amine
(3-Aminopropyl)triethoxysilane
3-Aminopropyltriethoxysilane
APTES
BRB Silanil 919
CG-550
coupling agent
DOW CORNING(R) Z-6011
DOW CORNING(R) Z-6011 SILANE
Dynasylan(R) AMEO
Dynasylan(R) AMEO T
JH-A110
KH-550
Organosilane A302
SG-Si1100
SILQUEST A-1100 SILANE
SILQUEST A-1100 Silane A-1100 A 1100; A 1112; AGM 9; UC-A 1100; Aktisil AM; AMEO; Silane 1100; APTES; Dynasylan AMEO Dynasylan AMEO-P Prosil 220; CA750 NUCA 1100;
SILQUEST A-1102 SILANE
XIAMETER(R) OFS-6011
aminopropyltriethoxysilane
1020103-34-7
1020103-34-7
1044532-60-6
1044532-60-6
106096-79-1
106096-79-1
12738-50-0
12738-50-0
130730-84-6
130730-84-6
131641-77-5
131641-77-5
1392103-81-9
1392103-81-9
143178-71-6
143178-71-6
159778-17-3
159778-17-3
1686133-96-9
1686133-96-9
204987-58-6
(3-Aminopropyl)triethoxysilane
APTES
3-(TRIETHOXYSILYL)PROPYLAMINE
1-Propanamine, 3-(triethoxysilyl)-
3-(triethoxysilyl)propan-1-amine
Propylamine, 3-(triethoxysilyl)-
gamma-Aminopropyltriethoxysilane
3-Triethoxysilylpropylamine
Nuca 1100
Silicone A-1100
Silane 1100
Aminopropyltriethoxysilane
Triethoxy(3-aminopropyl)silane
3-triethoxysilylpropan-1-amine
3-(Triethoxysilyl)-1-propanamine
Uc-A 1100
Silane, (3-aminopropyl)triethoxy-
AGM-9
AGM 9
NSC 95428
A 1100
A 1112
3-triethoxysilyl-1-propanamine
Triethoxyaminopropylsilane
(.gamma.-Aminopropyl)triethoxysilane
3-AMINOPROPYL-TRIETHOXYSILANE
Triethoxy-3-aminopropylsilane
L8S6UBW552
3-(Triethoxysilyl)-1-propylamine
MFCD00008207
NSC-95428
Silane, (.gamma.-aminopropyl)triethoxy-
Silane amg-9
(gamma-Aminopropyl)triethoxysilane
MFCD01324904
Dynasylan AMEO
(aminopropyl)triethoxysilane
CAS-919-30-2
Hydrosil 2627
Prosil 220
Silicone A 1100
HSDB 5767
Aminopropyltriethoxysilane(KH550)
Silane, gamma-aminopropyltriethoxy-
aminopropyl triethoxysilane
EINECS 213-048-4
amino-propyl-triethoxysilane
BRN 1754988
UNII-L8S6UBW552
3-aminopropyl triethoxysilane
gamma-triethoxysilylpropylamine
A 1102 (silane derivative)
(3-Aminopropyl)triethoxylsilane
Dynasylan AMEO-P
Silsoft A-1100
aminopropyltriethoxy silane
Union Carbide A-1100
3-Aminopropltriethoxysilane
aminopropyl triethoxy silane
EC 213-048-4
3-aminopropytriethoxy silane
3-aminopropyltriethoxylsilane
NCIOpen2_007962
3-aminopropyltriethoxy silane
3-aminopropyltriethoxy-silane
C 50752
SCHEMBL18080
(3-triethoxysilyl)propylamine
4-04-00-04273 (Beilstein Handbook Reference)
3-aminopropyl(triethoxy)silane
3-(triethoxysilyl) propylamine
3-(triethoxysilyl)-propylamine
(3-aminopropyl)-triethoxysilane
gamma-aminopropyl-triethoxysilane
CHEMBL1542365
DTXSID2027333
gamma-Aminopropyltriethoxy silane
Xiameter(R) OFS-6011 silane
gamma-aminopropyl triethoxy silane
(C2H5O)3Si(CH2)3NH2
Aminopropyl triethoxysilane [INCI]
HY-D0175
NSC95428
WLN: Z3-SI-O2&O2&O2
Tox21_201446
Tox21_303330
BBL027698
STK802166
(3-Aminopropyl)triethoxysilane, 99%
3-(Triethoxysilyl)propylamine [HSDB]
AKOS008901315
ZINC169743031
.GAMMA.-AMINPROPYLTRIETHOXYSILANE
.GAMMA.-TRIETHOXYSILYLPROPYLAMINE
(3-Aminopropyl)triethoxysilane, >=98%
NCGC00090985-01
NCGC00090985-02
NCGC00090985-03
NCGC00257040-01
NCGC00258997-01
AS-14523
BP-31043
(3-Aminopropyl)triethoxysilane, >=98.0%
DB-028361
A0439
CS-0010101
FT-0615063
D72483
EN300-371067
S00800
A844104
Q-200014
Q4542878
3-(Triethoxysilyl)-1-propylamine 100 microg/mL in Acetonitrile
(3-Aminopropyl)triethoxysilane, packaged for use in deposition systems, >=98%
3-Aminopropyltriethoxysilane, 98%, contained in 50 ml Swagelok? cylinder for CVD/ALD
(3-Aminopropyl)triethoxysilane [Wiki]
(γ-Aminopropyl)triethoxysilane
1-Propanamine, 3- (triethoxysilyl)-
1-Propanamine, 3-(triethoxysilyl)- [ACD/Index Name]
213-048-4 [EINECS]
3-(Triethoxysilyl)-1-propanamin [German] [ACD/IUPAC Name]
3-(Triethoxysilyl)-1-propanamine [ACD/IUPAC Name]
3-(Triéthoxysilyl)-1-propanamine [French] [ACD/IUPAC Name]
3-(triethoxysilyl)propan-1-amine
3-(Triethoxysilyl)propylamine
3-aminopropyl triethoxysilane
3-aminopropyl(triethoxy)silane
3-aminopropyltriethoxy silane
3-aminopropyl-triethoxysilane
3-Aminopropyltriethoxysilane
3-Triethoxysilylpropylamine
919-30-2 [RN]
Aminopropyltriethoxysilane
APTES
APTS
L8S6UBW552
MFCD00008207 [MDL number]
Propylamine, 3- (triethoxysilyl)-
Silane, (γ-aminopropyl)triethoxy-
γ-Aminopropyltriethoxy silane
γ-aminopropyltriethoxysilane
(3-​aminopropyl)​triethoxysilane
(3-Aminopropyl)triethoxysilane; 3-Triethoxysilylpropylamine; APTES; APTS
(3-Triethoxysilylpropylamine)
(γ-Aminopropyl)triethoxysilane
29159-37-3 [RN]
3-​aminopropyltriethoxy​silane
3-(Triethoxysilyl)propan-1-amin
3-(Triethoxysilyl)-propylamine
3-amino propyl triethoxysilane
3-aminopropyl triethoxy silane
3-aminopropyl(triethoxyl)silane
3-Aminopropyltriethoxysilan
3-aminopropyltriethoxy-silane
3-amino-propyltriethoxysilane
3-triethoxysilyl-1-propanamine
3-triethoxysilylpropan-1-amine
4-04-00-04273 [Beilstein]
aminopropyl triethoxysilane
aminopropyltriethoxy silane
aminopropyl-triethoxysilane
amino-propyl-triethoxy-silane
Aminopropyltriethoxysilane(KH550)
NCGC00090985-02
Propylamine, 3-(triethoxysilyl)-
Propylamine, 3-(triethoxysilyl)- (8CI)
Prosil 220
Silane, (3-aminopropyl)triethoxy-
silane, 3-aminopropyltriethoxy-
Silane, γ-aminopropyltriethoxy-
Triethoxy(3-aminopropyl)silane
Triethoxyaminopropylsilane
Uc-A 1100
UNII-L8S6UBW552
Z3-SI-O2&O2&O2 [WLN]
γ-aminopropyl triethoxysilane
γ-aminopropyltriethoxysilane