APPLE PEEL EXTRACT

Apple Peel extract helps lower blood cholesterol levels 
Apple Peel extract also contains polyphenols with antioxidant effects.

Cas Number: 85251-63-4
EC Number: 286-475-7

SYNONYMS:
Apple, Malus sylvestris, ext., PYRUS MALUS (APPLE) FRUIT EXTRACT, Malussylvestrisextract, Apple extract (malus sylvestris), Einecs 286-475-7, Malus sylvestris ext., Malussylvestrisextract, Apple extract (malus sylvestris), Einecs 286-475-7, Apple, Malus sylvestris, ext., PYRUS MALUS (APPLE) FRUIT EXTRACT, Malus sylvestris ext., Malussylvestris, pyrus malus fruit juice, Apple, Malus sylvestris, ext., PYRUS MALUS (APPLE) FRUIT EXTRACT, Malussylvestrisextract, Apple extract (malus sylvestris), Einecs 286-475-7, Malus sylvestris ext.

Apple Peel Extract is made from Australian Granny Smith Apples. 
The growing temperature ranges from -10 to 40 degrees celsius. 

This unique climate creates a unique phenolic profile.
Evidence suggest that Apple Peel extract has a wide range of polyphenols having antioxidant activity and its consumption has been linked with improved health benefits. 

Arsenic trioxide (ATO) is a very effective drug for the treatment of acute promyelocytic leukemia (APL) but it leads to cardiotoxicity mediated through alterations in various cardiac ion channels and by increasing the intracellular calcium level and reactive oxygen species (ROS). 
The aim of the present investigation was to study the effect of methanolic extract of Apple Peel extract (APME) and aqueous extract of Apple Peel extract (APAE) on ATO (5 μM) induced toxicity in the H9c2 cardiac myoblast cell line. 

We estimated the cellular status of innate antioxidant enzymes, level of ROS, mitochondrial superoxide, glutathione and intracellular calcium with ATO and Apple Peel extract extracts. 
Prior to the cell line based study, we had evaluated the antioxidant potential of Apple Peel extract extract by 1,1-diphenyl-2-picrylhydrazyl (DPPH), total reducing power (TRP), superoxide anion and hydroxyl radical scavenging activity, in addition to quantifying total phenolic and flavonoid content. 

Both the extracts showed considerable antioxidant activity in cell-free chemical assays. 
In addition, both APME and APAE prevented the alteration in antioxidant status induced by ATO in H9c2 cells. 

Significant differential alterations had been observed in the activity of lactate dehydrogenase, superoxide dismutase, catalase, glutathione, glutathione peroxidase, thioredoxin reductase, xanthine oxidase, calcium overload and caspase 3 activity with ATO. 
The overall result revealed the protective property of polyphenol-rich Apple Peel extract extract against ATO induced cardiac toxicity via its antioxidant activity.

USES and APPLICATIONS of APPLE PEEL EXTRACT:
Cosmetic Uses of Apple Peel extract: antioxidants, skin conditioning, and skin protecting agents.

MEDICINE USES OF APPLE PEEL EXTRACT:
Apple Peel extract helps lower blood cholesterol levels 
Apple Peel extract also contains polyphenols with antioxidant effects.

Vitamin C, iron, boron, and so on including rich content. 
These ingredients are one of the most important factors to make your bone structure healthy and strong.
Flavonoids and phenolic acids have been shown to be effective in preventing the development of tumors and cancerous cells. 

These compounds are found in Apple Peel extract.
Sorbitol in the Apple Peel extract draws water to the colonic colon and prevents constipation
Vitamin A helps to improve eye vision and prevent eye disorders.

COSMETIC USES OF APPLE PEEL EXTRACT:
*SKIN CARE:
Skin lightening, brightening and soothing potential. 
This is because Apple Peel extract has the highest content in collagen and elastic content, which is vital to keep your skin flawless and youthful.

Apple Peel extract cleanses the skin while moisturizing. 
Apple Peel extract is an excellent anti-aging mask.
Corrects acne, blemishes and bruises on the skin,

*HAIR CARE:
Apple Peel extract provides vitality and parking.

FOOD USES OF APPLE PEEL EXTRACT:
Apple Peel extract is used as aroma donor,
Apple Peel extract is used as a natural colorant.
Apple Peel extract is used as food supplement,

VETERINARY MEDICINE USES OF APPLE PEEL EXTRACT:
Apple Peel extract is prevention of intestinal problems,
Apple Peel extract is used ntioxidant,

Treatment of bone diseases,
Apple Peel extract is used as aroma donor.
Apple Peel extract contain concentrated amounts of phytonutrients – up to 6 times more than the flesh of the fruit

NUTRIENT DENSE! 
Rich in fibre, Vitamin C, and made with a gentle low temperature air-drying process to ensure optimal nutritional integrity

WHAT IS APPLE PEEL EXTRACT?
Pyrus malus is the scientific name for the apple. 
Apple-derived ingredients (Pyrus Malus (Apple) Fiber, Pyrus Malus (Apple) Flower Extract, Pyrus Malus (Apple) Fruit, Pyrus Malus (Apple) Fruit Extract, Pyrus Malus (Apple) Fruit Water, Pyrus Malus (Apple) Fruit Juice, Pyrus Malus (Apple) Leaf Extract, Pyrus Malus (Apple) Oil, Pyrus Malus (Apple) Pectin Extract, Pyrus Malus (Apple) Peel Extract, Pyrus Malus (Apple) Peel Powder, Pyrus Malus (Apple) Peel Wax, Pyrus Malus (Apple) Root Extract, Pyrus Malus (Apple) Seed Extract, Pyrus Malus (Apple) Seed Oil, Pyrus Malus (Apple) Stem Extract) are obtained from the fruit, leaf, stem, root or flower of the plant 
Pyrus malus. 

In cosmetics and personal care products, the ingredients derived from Pyrus malus are used in the formulation of a wide variety of products including hair conditioners, hand and body lotions, and shampoos.

WHY IS APPLE PEEL EXTRACT USED?
The following functions have been reported for ingredients derived for Pyrus malus.
Antioxidant: Pyrus Malus (Apple) Peel Extract
Binder: Pyrus Malus (Apple) Fiber

Cosmetic astringent: Pyrus Malus (Apple) Fruit
Emulsion stabilizer: Pyrus Malus (Apple) Fiber
Exfoliant: Pyrus Malus (Apple) Peel Powder

Fragrance ingredient: Pyrus Malus (Apple) Fruit Water
Skin conditioning agent -emollient: Pyrus Malus (Apple ) Seed Oil
Skin conditioning agent – miscellaneous: Pyrus Malus (Apple) Flower Extract, Pyrus Malus (Apple) Fruit Extract, Pyrus Malus (Apple) Juice, Pyrus Malus (Apple) Oil, Pyrus Malus (Apple) Root Extract, Pyrus Malus (Apple) Seed Extract, Pyrus Malus (Apple) Stem Extract

Viscosity controlling agent: Pyrus Malus (Apple) Fiber
Viscosity increasing agent – aqueous: Pyrus Malus (Apple) Fiber
Scientific Facts
The apple tree was perhaps the earliest tree to be cultivated, and apples have remained an important food in all cooler climates.

SAFETY INFORMATION ABOUT APPLE PEEL EXTRACT:
Apples, the fruit of the plant from which these ingredients are derived, are listed by the Food and Drug Administration (FDA) among the 20 most commonly consumed fruits. 
The FDA includes pectin, including pectin derived from apples, on its list of substances considered Generally Recognized as Safe (GRAS) as direct food substances. 

Botanical and botanically derived ingredients used in the formulation of cosmetics are generally mild and safe. 
Prior to marketing the finished cosmetic product, the safety of each ingredient must be substantiated in accordance with 21 CFR 740.10. 
Safety substantiation of cosmetic ingredients may include tests for ocular and skin irritation as well as allergenicity, phototoxicity, photoallergenicity and mutagenicity, depending on the application or intended use. 

There is a considerable body of information about the safety of botanical ingredients and a well established history of use. 
These resources are consulted to ensure the safety of these materials as they are used in cosmetics.

PHYSICAL and CHEMICAL PROPERTIES of APPLE PEEL EXTRACT:
Product Name: Apple Peel Extract / Apple Peel Extract
Botanical Name: Pyrus Malus
Pearl Name: Pyrus Malus Peel Extract
CAS No: 85251-63-4
EINECS: 286-475-7
Part Used: Shell
Harvest Time: Winter
Product Form: Powder
Production Method: Extraction
Resolution: Water / Oil
Botanical Name: Pyrus Malus
CAS: 89957-84-3
INCI: Pyrus Malus Extract
Description: 100% Apple Peel Extract

Production Methodology: Ethanol and Water Extraction
CAS Number: 85251-63-4
Chem/IUPAC Name: Pyrus Malus Fruit Extract is an extract of the fruit of 
the Apple, Pyrus malus L., Rosaceae
EINECS/ELINCS No: 286-475-7
CAS Number: 85251-63-4
Molecular Weight: N/A
Density: N/A
Boiling Point: N/A
Molecular Formula: N/A
Melting Point: N/A
MSDS: N/A
Flash Point: N/A

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /Density: N/A
Refractive Index: N/A
Storage Temp.: N/ASolubility: N/ACAS DataBase Reference: Apple, Malus sylvestris, ext.
NIST Chemistry Reference: Apple, Malus sylvestris, ext.(85251-63-4)
EPA Substance Registry System: Apple, Malus sylvestris, ext.(85251-63-4)
CAS NO:85251-63-4
Molecular Formula:
Molecular Weight: 0
EINECS: 286-475-7
Product Categories: N/A
Mol File: 85251-63-4.mol

FIRST AID MEASURES of APPLE PEEL EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of APPLE PEEL EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of APPLE PEEL EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of APPLE PEEL EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of APPLE PEEL EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of APPLE PEEL EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available