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Bitter sophora Root extract acts as an anti-bacterial and anti-inflammatory agent.
Bitter sophora Root extract contains alkaloids like matrine and oxymatrine.
Bitter sophora Root extract relieves internal heat and suppresses tumors.
CAS Number: 519-02-8
Molecular Formula: C15H24N2O
Molecular Weight: 248.36
EINECS Number: 610-750-6
Synonyms: Matrine, 519-02-8, (+)-Matrine, Matridin-15-one, Vegard, alpha-Matrine, Matrene, (+)-, (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, NSC 146051, UNII-N390W430AC, BRN 0085851, CHEBI:6700, N390W430AC, NSC-146051, .alpha.-Matrine, DTXSID00274188, 5-24-02-00301 (Beilstein Handbook Reference), MFCD00210527, NSC-318810, C15H24N2O, Matrinium, Matrine,(S), MATRINE [MI], Matrine ((+)-Matrine), MATRINE [WHO-DD], SCHEMBL177907, CHEMBL204860, DTXCID70820575, HMS3884F13, AMY25701, BCP08193, HY-N0164, BDBM50249581, Matridin-15-one; Vegard; -Matrine, NSC146051, s2322, Matridin-15-one;Vegard;alpha-Matrine, AKOS007930266, CCG-208589, CS-1601, KS-5203, Matrine 100 microg/mL in Acetonitrile, NCGC00346593-01, 1ST000575, M2120, NS00066991, (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one, (7aS,13aR,13bS,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one, 1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)-.
Bitter sophora Root extract finds application in formulating cosmetic products.
Bitter sophora Root extract has a shelf life of 2 years.
Bitter sophora Root extract is an alkaloid found in plants from the Sophora genus.
It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and μ-receptor agonist.
Bitter sophora Root extract is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton.
The extraction process involves the use of organic solvents on dry roots, plants, and fruits of kushen 苦参 (Sophora flavescens Ait).
Bitter sophora Root extract is also present in S. alopecuroides L. and S. subprostrata Chun et T. Chen.
Bitter sophora Root extract is a white crystal or powder in the form of needles, which can turn yellow with prolonged exposure to air.
It is soluble in water, benzene, chloroform, and methanol, but only slightly soluble in petroleum ether.
Bitter sophora Root extract has a melting point of 76°C (α-matrine), 87°C (β-matrine), 223°C (γ-matrine), and 84°C (δ-matrine), and a specific optical rotation of +31 to +36°.
As early as the 1930s, the Soviet Union began to study Sophora flavescens, and the china research began in 1972.
Bitter sophora Root extract in the chemical composition are divided into two major categories of alkaloids and flavonoids.
Bitter sophora Root extract has antiarrhythmic, anti-inflammatory, anti-fibrosis, and anti-tumor effects.
It has significant effects of negative frequency and positive inotropic action, which can enhance myocardial contractility, slow down the heart rate, and extend the PR and QTC interval.
Bitter sophora Root extract can promote the expression of the bcl-2 gene and can improve the ratio of bcl-2/Bax to inhibit apoptosis of myocardial cell caused by myocardial ischemia reperfusion and then reduce myocardial deficiency caused by coronary atherosclerotic heart disease and myocardial infarction to achieve the role of antiarrhythmic.
In addition, Bitter sophora Root extract can also play an anti-pulmonary fibrosis effect by inhibiting the proliferation of lung fibroblasts and the expression of pulmonary interstitial fibroblasts (FN).
Bitter sophora Root extract has multiple pharmacological effects and can treat a variety of diseases in clinical setting.
At present, the researches on Bitter sophora Root extract are mainly focused on antiliver injury and liver fibrosis and anti-tumor and anti-cardiovascular diseases.
It was worthy of attention that Bitter sophora Root extract has other pharmacological activities, such as leukocyte-elevating effects and anti-virus effects, and these effects were necessary for further development and utilization.
The pharmacological effects of matrine stayed in the experimental phase, and they need further development and research to promote the development of clinical practice.
Improvements in the modern formulation of Bitter sophora Root extract can improve their clinical application.
Bitter sophora Root extract mainly contains alkaloids, flavonoids, quinones, and triterpenoid saponins.
Bitter sophora Root extract, oxymatrine, sophoridine, sophoranol, sophoramine, etc.
Bitter Sophora Root Extract is derived from the root of the plant Sophora flavescens, a traditional medicinal herb primarily used in Chinese medicine.
Bitter sophora Root extract is known for its range of bioactive compounds, with matrine and oxymatrine being the most notable alkaloids.
Used in traditional Chinese medicine to treat various ailments, including inflammation, viral infections, and skin conditions.
Due to its anti-inflammatory, antiviral, and antimicrobial properties, Bitter Sophora Root Extract is used in modern herbal medicine and skincare products.
Bitter sophora Root extract's also studied for potential benefits in treating liver diseases, cancer, and cardiovascular issues.
The extract can be found in various forms, such as powders, capsules, and tinctures.
Melting point: 77 C
Boiling point: 86-88C/2,5Torr
alpha: D20 +38° (alc)
Density: 1,191g/cm
refractive index: 1,536
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Water (up to 25 mg/ml)
pka: 9.47±0.20(Predicted)
form: solid
color: White
optical activity: +37.926 (c 1.69, H2O)
Merck: 14,5759
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
LogP: 1.440 (est)
In clinical settings, Bitter sophora Root extract injection was used for chronic active hepatitis, and suppository was used for trichomoniasis or Candida vaginitis and chronic cervicitis and can also be used for senile vaginitis and pelvic inflammatory disease.
Bitter sophora Root extract was able to inhibit gastric cancer cell line mnk45 in a dose-dependent manner.
Bitter sophora Root extract the concentration required for 50% inhibition (ic50) was found to be 540 μg/ml.
This anti-tumor function was achieved through modulation of the nf-κb, xiap, ciap, and p-erk proteins expression in cell line mnk45.
Bitter sophora Root extract induces apoptosis of human nsclc cells with anti-apoptotic factors inhibited and dependent on caspase activity.
In addition, found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with sb202190 partially prevents matrine-induced apoptosis.
Furthermore, matrine generates reactive oxygen species (ros) in a dose- and time-dependent manner, which is reversed by pretreatment with n-acetyl-l-cysteine (nac).
Bitter Sophora Root Extract is obtained from the roots of Sophora flavescens, also known as Ku Shen in traditional Chinese medicine.
This perennial plant belongs to the legume family (Fabaceae) and is native to East Asia, particularly China, Japan, and Korea.
The most studied alkaloids in Bitter Sophora Root Extract.
Bitter sophora Root extracts are primarily responsible for the extract's pharmacological effects, including anti-inflammatory, antiviral, and anticancer activities.
In addition to Bitter sophora Root extract and oxymatrine, the extract contains other bioactive components such as sophoridine, kurarinone, and flavonoids, which contribute to its medicinal properties.
Traditionally used to reduce inflammation in various conditions, such as arthritis and skin disorders like eczema and psoriasis.
Employed to treat infections, including viral infections like hepatitis and certain bacterial infections.
Bitter sophora Root extract used to alleviate gastrointestinal issues, such as diarrhea and dysentery, due to its antispasmodic and antimicrobial properties.
Applied topically to treat skin ailments like eczema, dermatitis, and fungal infections.
Bitter sophora Root extract and oxymatrine have been researched for their potential to inhibit the growth of various cancer cells, including liver, lung, and breast cancer.
They work by inducing apoptosis (programmed cell death) in cancer cells and inhibiting tumor growth.
Some studies suggest that compounds in Bitter Sophora Root Extract may help lower blood pressure and reduce the risk of atherosclerosis, contributing to cardiovascular health.
Bitter sophora Root extract has hepatoprotective effects, meaning it can help protect the liver from damage caused by toxins, viruses, and certain medications.
This is particularly relevant in the treatment of hepatitis and other liver diseases.
Modern studies have confirmed the extract's ability to reduce inflammation, making it potentially useful for treating chronic inflammatory conditions.
Ongoing research is exploring its efficacy against viruses, including hepatitis B and C, HIV, and influenza.
Commonly available as dietary supplements.
Found in creams, ointments, and lotions for treating skin conditions.
Bitter sophora Root extract used for more precise dosing in herbal medicine practices.
Bitter sophora Root extract is generally considered safe when used appropriately, it can cause side effects such as nausea, vomiting, or allergic reactions in some individuals.
Bitter sophora Root extract should be used with caution, especially in those with existing health conditions or those taking other medications.
Due to its potent effects, it's important to consult with a healthcare provider before using this extract, particularly in higher doses or for extended periods.
Uses:
Bitter sophora Root extract is an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects.
Bitter sophora Root extract is used to alleviate symptoms of inflammation-related conditions such as arthritis, eczema, and dermatitis.
The extract's anti-inflammatory properties are being explored in the treatment of chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.
Bitter sophora Root extract is used to treat bacterial infections, fungal infections, and viral conditions like hepatitis.
Research supports its effectiveness against various microbes and viruses.
Bitter sophora Root extract is being studied for potential use in treating viral infections such as hepatitis B and C, and HIV.
Bitter sophora Root extract and oxymatrine, two key alkaloids in the extract, have shown promise in inhibiting the growth of cancer cells in various types of cancer, including liver, lung, and breast cancer.
They help induce apoptosis (cell death) in cancer cells and inhibit tumor growth.
The extract has been studied for its potential to lower blood pressure and reduce the risk of atherosclerosis, which can help in managing cardiovascular diseases.
Bitter sophora Root extract is used to protect the liver and treat liver-related conditions like hepatitis.
Bitter sophora Root extract's hepatoprotective properties are recognized for safeguarding the liver from toxins, viruses, and medications that can cause liver damage.
Employed to treat gastrointestinal issues such as diarrhea, dysentery, and other digestive disorders.
Bitter sophora Root extracts antispasmodic and antimicrobial properties continue to make it a valuable remedy for digestive health.
Applied topically to treat various skin conditions, including eczema, psoriasis, and fungal infections.
Available in creams and ointments for treating skin inflammations, irritations, and infections.
Bitter sophora Root extract's immune-modulating properties are being researched for boosting the immune system and helping the body fight off infections.
Used to alleviate pain associated with various conditions, such as inflammation and injury.
Its analgesic (pain-relieving) properties are utilized in herbal medicine for managing pain without the side effects associated with synthetic painkillers.
Preliminary research suggests that the extract may help reduce cravings and withdrawal symptoms associated with opioid addiction, though more studies are needed to confirm its efficacy.
The extract has antioxidant properties, helping to neutralize free radicals in the body, which can prevent cellular damage and reduce the risk of chronic diseases.
In Chinese medicine, Sophora flavescens has been used to treat respiratory conditions such as bronchitis and asthma.
Bitter sophora Root extract is believed to reduce inflammation in the airways, making it potentially useful in managing chronic respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD).
Its antiviral properties also suggest benefits in combating respiratory infections, including those caused by influenza viruses.
Emerging research suggests that Bitter Sophora Root Extract might offer neuroprotective benefits, helping to protect nerve cells from damage.
This is particularly relevant in the context of neurodegenerative diseases such as Alzheimer's and Parkinson's.
Bitter sophora Root extract's ability to reduce oxidative stress and inflammation in the brain could be key to these protective effects.
Historically, Sophora flavescens was used to treat parasitic infections, such as those caused by helminths (worms).
Bitter sophora Root extract has demonstrated efficacy against a variety of parasites, including Leishmania species (responsible for leishmaniasis) and Plasmodium species (the cause of malaria).
This makes it a candidate for use in antiparasitic treatments, especially in regions where such infections are prevalent.
Bitter Sophora Root Extract is being studied for its potential to manage metabolic disorders.
Some studies suggest that it might help regulate blood sugar levels, making it beneficial for people with diabetes or those at risk of developing the condition.
Additionally, its effects on lipid metabolism could aid in controlling cholesterol levels, thus supporting overall metabolic health.
There's interest in using Bitter Sophora Root Extract as an adjunct therapy in cancer treatment.
Some studies suggest that the Bitter sophora Root extract can enhance the effectiveness of certain chemotherapeutic agents while reducing their side effects.
This is particularly relevant in managing chemotherapy-induced toxicity, including liver and kidney damage, as well as improving the overall quality of life for cancer patients.
Safety Profile:
Bitter sophora Root extract contains potent alkaloids like matrine and oxymatrine, which, in excessive amounts, can be toxic.
Overdose can lead to symptoms such as nausea, vomiting, dizziness, headaches, and in severe cases, respiratory distress or even convulsions.
Prolonged or high-dose use of the extract may cause liver toxicity, particularly in individuals with pre-existing liver conditions or those taking other hepatotoxic medications.
Topical application of Bitter Sophora Root Extract can cause allergic reactions or skin irritation in some individuals, leading to redness, itching, or rash.
Ingesting the extract can trigger systemic allergic reactions in sensitive individuals, ranging from mild symptoms like itching or swelling to more severe reactions such as anaphylaxis.
Because the extract can modulate the immune system, it may interfere with the effectiveness of immunosuppressive medications used in conditions like organ transplantation or autoimmune diseases.
Bitter sophora Root extract's potential to lower blood pressure may enhance the effects of antihypertensive drugs, leading to hypotension (abnormally low blood pressure), dizziness, or fainting.
Bitter sophora Root extract may interact with blood-thinning medications, increasing the risk of bleeding.
