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DIMETHYETHANOLAMINE (Dimethylaminoethanol, DMAE, DMEA, Dimethyl ethanol amine) is an organic compound with the formula (CH₃) ₂NCH₂CH₂OH. It is bifunctional, involving both tertiary amine and high alcohol conductivity. It is a colorless viscous liquid. It is used in skin care products. It is prepared by the ethoxylation of dimethylamine.
DIMETHYETHANOLAMINE SYNONYMS: 108-01-0; 1209235; 2- (Dimethylamino) -1-ethanol; 2- (Dimethylamino) ethanol; 2- (Dimethylamino) ethanol; 2- (Dimethylamino) ethanol; 203-542-8; 2-DIMETHYLAMINOETHANOL; 2-Dwumetyloaminoethanol; 2N6K9DRA24; 4-11-00-00122; Deanol; Dimethyl (2-hydroxyethyl) amine; Dimethyl (hydroxyethyl) amine; Dimethylaethanolamine; Dimethylaminoaethanol;
DMAE; DMEA; Ethanol, 2- (dimethylamino) -KK6125000; MFCD00002846; N- (2-Hydroxyethyl) dimethylamine; N, N-Dimethyl-2-aminoethanol; N, N-Dimethyl-2-hydroxyethylamine; N, N-Dimethylethanolamine; N, N-Dimethyl-N- (2-hydroxyethyl) amine; N, N-Dimethyl-N- (-hydroxyethyl) amine; UNII-2N6K9DRA24; p-Dimethylaminoethyl alcohol; p-Hydroxyethyldimethylamine; (2-Hydroxyethyl) dimethylamine; (CH3) 2NCH2CH2OH; (Dimethylamino) ethanol; 116134-09-9 alternative RN; 2- (Dimethylamino) ethanol; 2- (dimethylamino) ethan-1-ol; 2- (Dimethylamino) -ethanol; 2- (N, N-Dimethylamino) ethanol; 2-Dimethylamino ethanol; 2-Dimethylamino-ethanol; Amietol M 21; Bimanol; Demanol, Dimethylaminoethanol; Dimethylethanoiamine; Dimethylethanolamine; Dimethylmonoethanolamine; Kalpur P; Liparon; N- (Dimethylamino) ethanol; N, N-Dimethylethanolamine; N, N-Dimethyl ethanolamine; N, N-Dimethyl (2-hydroxyethyl) amine; N, N-dimethylaminoethanol; N, N'-Dimethylethanolamine; N, N-Dimethyl-N- (-hydroxyethyl) amine; N, N-Dimethyl-N- (-hydroxyethyl) amine; N, N-Dimethyl-N-ethanolamine; N, N-Dimethyl-N-ethanolamine; N, N-Dimethyl-p-hydroxyethylamine; N, N-Dimethyl-p-hydroxyethylamine; N-Benzyloxycarbonyl-L-tyrosine; N-dimethyl aminoethanol; N-Dimethylaminoethanol
Norcholine; Propamine A; Q2N1 & 1; Texacat; DME; UN 2051; Varesal; - (dimethylamino) ethanol; β - (dimethylamino) ethyl alcohol; p-dimethylaminoethyl alcohol; p-hydroxyethyldimethylamine; -(Dimethylamino) ethanol; -(Dimethylamino) ethyl alcohol; p-Dimethylaminoethyl alcohol; p-Hydroxyethyldimethylamine; 391263_ALDRICH; 471453_ALDRICH; AI3-09209; BRN 1209235; CCRIS 4802; HSDB 1329; MFCD00035067; NCGC00159413-02; NSC 2652; NSC2652; PubChem Item ID 32975581; ST5214432; UN2051; UNII: 2N6K9DRA24
DIMETHYETHANOLAMINE PRODUCT INFORMATION
Substance Name: (DIMETHYLAMINO)
DIMETHYETHANOLAMINE Other names: deanol, dimethylaminoethanol, dimethylaminoethanol
DIMETHYETHANOLAMINE CAS No: 108-01-0
DIMETHYETHANOLAMINE Abbreviations: DMAE, DMEA
DIMETHYETHANOLAMINE Beilstein Reference: 1209235
ChEBI CHEBI: 271436
ChEMBL ChEMBL: 1135
ChemSpider: 13854944
ECHA Info Card: 100.003.221
EC Number: 203-542-8
KEGG: D07777
MeSH: Deanol
PubChem Client ID: 7902
RTECS number: KK6125000
UNII: 2N6K9DRA24
DIMETHYETHANOLAMINE UN number: 2051
CompTox Control Panel (EPA): DTXSID2020505
DMAE (DIMethylaminoethanol) is a compound known as a mental health compound. It does this by reducing its accumulation known as age pigment, which impairs cognitive function and is associated with cognitive decline with age. Also, memory can increase the levels of the acetylcholine-containing compound.
DMAE (DIMETHYLAMINOETHANOL) is also found in a variety of face and body creams and can tighten the skin and improve skin quality. Dimethylaminoethanol DMAE is a new ingredient originally used to treat hyperkinetic disorders and to improve memory. It is now used in cosmeceutical products and is gaining popularity from its activity as an acetylcholine precursor. Originally used as a firming and anti-aging product, new functions have now been clarified, including anti-inflammatory and antioxidant activities. In vitro, DMAE inhibits IL-2 and IL-6 secretion in addition to its effects as a free radical scavenger. Although the exact mechanism of action of DMAE is not clear, its acetylcholine-like functions increase the contraction and cell adhesion in the epidermis and dermis, resulting in a firmer skin appearance.Double-blind trials with 3% DMAE facial gel improve the firmness and muscle tone of the facial skin as evidenced by reduced neck sagging. showed that it increased. Topical formulations with a low irritation profile are now also available. There are several well-controlled studies documenting its long-term efficacy and toxicity. Discharge into the environment must be avoided.
To execute the full range of specific RMM and OC required to fulfill commitment under community environmental legislation.Adequately control the impact of MEA on the environment is given in the exposure scenarios, annexed to the SDS. The product is not intended for use in the home.
Health benefits: DMAE is supposed to increase the production of acetylcholine (a chemical that helps nerve cells transmit signals). Because acetylcholine plays an important role in many brain functions such as learning and memory, supporters claim that taking DMAE in supplement form can boost brain health by raising acetylcholine levels. Drugs that increase acetylcholine levels have been used to treat Alzheimer's disease, so some studies have looked at DMAE as a potential Alzheimer's treatment. However, they haven't shown any promising results so far.DMAE has been used in some way to treat attention deficit / hyperactivity disorder (ADHD), but there is only weak evidence behind this use. A 2011 study on nutritional treatments noted that it "probably had a minor effect." Additionally, DMAE has been studied to improve athletic performance, elevate mood, and address symptoms of depression.
Skin Care Products: DMAE cream, lotion and other skin care products are said to provide anti-aging benefits by reducing the appearance of wrinkles, dark under-eye circles and sagging neck skin. While research on the effectiveness of DMAE is very limited, there is some evidence that using DMAE-based products can help improve skin. For example, a review published in the American Journal of Clinical Dermatology states that DMAE can help increase skin firmness and reduce inflammation in the skin. In an analysis of previously published research, the authors of the review found that DMAE can help reduce fine wrinkles on the forehead and around the eyes and improve the overall appearance of aging skin. What's more, the authors of the review noted that DMAE did not cause common side effects such as redness, peeling, and dryness.
Cognitive Function: In a study published in the Journal of Alzheimer's Disease in 2012, 242 people (all diagnosed with early-stage Alzheimer's disease) took a placebo or an oral DMAE extract known as V0191 every day for 24 weeks. At the end of the study, there was no significant difference in cognitive function between the two groups. Studies noted that there may be a few issues in the study design, including a relatively short treatment duration, lack of valid measures to evaluate study participants, and problems with assessing changes in cognitive function over time, and there is no evidence that oral DMAE supplements can treat depression or improve sports performance.
Possible side effects: Little is known about the safety of DMAE supplements. However, there is some concern that DMAE may trigger certain side effects, including increased blood pressure, stomach upset, headache, muscle tension, lethargy, confusion, and irritability. DMAE should not be taken because of concern it might cause. Also, people with bipolar disorder or epilepsy should not use DMAE. You can find tips on using supplements here.
When used topically, DMAE may cause skin irritation.
Dosage and Preparation: There is insufficient scientific evidence to determine a safe or effective DMAE dosage.There have been doses used in scientific studies. For example, in a study examining the athletic performance benefits of DMAE, study participants took 300 to 2000 mg of Deanol per day.The safe and effective dose for you may depend on variables including your age, gender, and medical history. Talk to your healthcare provider for personalized advice. Avoid sources of ignition such as heat, sparks and open flames. No smoking. Keep container tightly closed. Use non-sparking tools. When reloading electrostatically sensitive items, ground and connect the container and receiver. Explosion proof electrical equipment, ventilation equipment, lighting equipment, etc. Use it. Take precautionary measures against electrostatic discharge. Wash hands thoroughly after use. Do not inhale mist, vapors or sprays.
Use only outdoors or in well ventilated areas. Wear suitable protective gloves and clothing. Use suitable protective glasses and protective surfaces. Keep dirty work clothes away from the work place. Avoid release to the environment. Discharge into the environment must be avoided.
To execute the full range of specific RMM and OC required to fulfill commitment under community environmental legislation.
Adequately control the impact of MEA on the environment is given in the exposure scenarios, annexed to the SDS. The product is not intended for use in the home.
First aid: If it adheres to skin or hair, remove or remove all contaminated clothing immediately. Rinse skin with running water or shower. If it gets on your skin, wash with plenty of water and soap. In case of fire, use appropriate fire extinguishing. Wash contaminated clothing before reuse. If inhaled, take victim to a place with fresh air and rest in a breathable position. contact.
In case of contact with eyes, rinse carefully with water for a few minutes. Then, if you wear contact lenses and can easily remove them, take them off. After that, continue to clean. If swallowed, rinse mouth. If skin adheres to skin, in eyes, swallows, or is pale, seek medical advice immediately. If skin adheres or skin irritation or rash occurs, seek medical attention and treatment. If you feel unwell, seek medical attention and treatment.
Storage: Keep container in a tightly closed and well-ventilated place. Store in a well-ventilated cool place. Lock and keep safe.
Disposal: Consign the contents and containers to a private waste disposal company licensed by the governorship.
CHARACTERISTICS OF DIMETHYETHANOLAMINE
Chemical formula: C 4 H 11 N O
Molar mass: 89.138 gmol −1
Appearance: Colorless liquid
Smell Fishy: ammonia
Density: 890 mg mL −1
Melting point: -59.00 ° C; -74.20 ° F; 214.15 K
Boiling point: 134.1 ° C; 273.3 ° F; 407.2 K Daily P: −0.25
Vapor pressure: 816 Pa (at 20 ° C)
Acidity (p K a): 9.23 (at 20 ° C)
Basicity (p K b): 4.77 (at 20 ° C)
Refractive index (n D): 1.4294
DIMETHYETHANOLAMINE DANGERS
GHS Signal word: Danger
GHS hazard statements: H226, H302, H312, H314, H332
GHS precautionary statements: P280, P305 + 351 + 338, P310
Flash point: 39 ° C (102 ° F; 312 K)
Explosive limits: 1.4--12.2%
Lethal dose or concentration (LD, LC): LD 50 (mean dose): 1.214 g kg-1 (dermal, rabbit) 2 g kg-1 (oral, rat)
