FUROSEMIDE

Furosemide is a loop diuretic medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.
Furosemide may also be used for the treatment of high blood pressure.
Furosemide can be taken by injection into a vein or by mouth.When taken by mouth, it typically begins working within an hour, while intravenously, it typically begins working within five minutes.

CAS Number: 54-31-9
EC Number: 200-203-6
IUPAC Name: 4-Chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
Chemical Formula: C12H11ClN2O5S

Other names: 4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID, 5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID, 5-[AMINOSULFONYL]-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID, LABOTEST-BB LT00244801, FUROSEMID, FUROSEMIDE, FRUSEMIDE, 2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid, FUROSEMIDE METHANOL SOLUTION, FUROSEMIDE, RELATED COMPOUND B 4-CHLORO-5-SULFAMOYLANTHRANILIC ACID USP STANDARD, FUROSEMIDE, EP STANDARD, FUROSEMIDE, IMP. A (EP):2-CHLORO-4-FURFURYLAMINO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD), FUROSEMIDE, IMP. B (EP): 2,4-DICHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD), FUROSEMIDE, MM(CRM STANDARD), FUROSEMIDE, WHO(CRM STANDARD), FUROSEMIDE, IMP. C (EP): 2-AMINO-4-CHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD), FUROSEMIDE, IMPURITY A2-CHLORO-4-(FURFURYLAMINO)-5-SULPHAMOYLBENZOIC ACID EP STANDARD, FUROSEMIDE, USP STANDARD, FUROSEMIDE, BP STANDARD(CRM STANDARD), FUROSEMIDE, RELATED COMPOUND A 2-CHLORO-4-N-FURFURYLAMINO-5-SULFAMOYLBENZOIC ACID USP STANDARD, FUROSEMIDE UNLABELED 1.0 MG/ML IN METHANOL, Furosemide for peak identification, ANTI-TM173(C-TERMINAL) antibody produced in rabbit, ERIS, TMEM173, Transmembrane protein 173, Furosemide (furosemide), Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-(2-furanylmethyl)amino-, FUROSEMIDE,1.0MG/MLINMETHANOL, FUROSEMIDE,USP, 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid, 4-CHLORO-N-(2-FURYLMETHYL)-5-SULPHAMOYLANTHRANILICACID, FUROSEMIDE (FRUSEMIDE), 5-(Aminosulfonyl)-4-chloro-2-[(2-pyranylmethyl)-amino]benzonium acid, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid, Furosemide solution, Furix, Furomex, Lazax, N-(2-furylmethyl)-4-chloro-5-sulfamylanthranilic acid, "mita", 4-chloro-n-(2-furylmethyl)-5-sulfanoylanthranilicacid, 4-chloro-n-furfuryl-5-sulfamoyl-anthranilicaci, 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-benzoicaci, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoicaci, 5-(Aminosulfonyl)-4-chloro-2-[2-(furamyl-methyl)amino]-benzoicacid, aluzine, aquasin, arasemide, chlor-n-(2-furylmethyl)-5-sulfamylanthranilsaeure, diurolasa, endural, franyl, frusemin, furanthril, furanthryl, furantril, furose

Common side effects include feeling lightheaded with standing, ringing in the ears, and sensitivity to light. Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss. Blood tests are recommended regularly for those on treatment.
Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys.Common side effects of furosemide injection include hypokalemia (low potassium level), hypotension (low blood pressure), and dizziness.

Furosemide was patented in 1959 and approved for medical use in 1964.
Furosemide is on the World Health Organization's List of Essential Medicines. In the United States, it is available as a generic medication. In 2019, it was the seventeenth most commonly prescribed medication in the United States, with more than 28 million prescriptions.
Furosemide is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs.
Furosemide has also been used in race horses for the treatment and prevention of exercise-induced pulmonary hemorrhage.

Medical uses
Furosemide (Lasix) for injection
Furosemide is primarily used for the treatment of edema, but also in some cases of hypertension (where there is also kidney or heart impairment).
Furosemide is often viewed as a first-line agent in most people with edema caused by congestive heart failure because of its anti-vasoconstrictor and diuretic effects. Compared with furosemide, however, torasemide has demonstrated to show improvements to heart failure symptoms, possibly lowers the rates of rehospitalisation associated with heart failure and has no difference in risk of death. Torsemide may also be safer than furosemide.

Furosemide is also used for liver cirrhosis, kidney impairment, nephrotic syndrome, in adjunct therapy for swelling of the brain or lungs where rapid diuresis is required (IV injection), and in the management of severe hypercalcemia in combination with adequate rehydration.

Kidney disease
In chronic kidney diseases with hypoalbuminemia, it is used along with albumin to increase diuresis.
Furosemide is also used along with albumin in nephrotic syndrome to reduce edema.

Other information
Furosemide is mainly excreted by tubular secretion in the kidney. In kidney impairment, clearance is reduced, increasing the risk of adverse effects.Lower initial doses are recommended in older patients (to minimize side-effects) and high doses may be needed in kidney failure.
Furosemide can also cause kidney damage; this is mainly by loss of excessive fluid (i.e. dehydration), and is usually reversible.
Furosemide acts within 1 hour of oral administration (after IV injection, the peak effect is within 30 minutes). Diuresis is usually complete within 6–8 hours of oral administration, but there is significant variation between individuals.

Uses
Furosemide is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen.This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Furosemide is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.

Furosemide is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This allows the salt to instead be passed in your urine.
Furosemide is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.

Furosemide is also used to treat high blood pressure (hypertension).
Furosemide is a type of medicine called a diuretic. It's used to treat high blood pressure, heart failure and oedema (a build up of fluid in the body).
Furosemide's also sometimes used to help you pee when your kidneys aren't working properly.
Furosemide is only available on prescription. 
Furosemide comes as tablets and as a liquid that you swallow. 
Furosemide can also be given by injection, but this is usually only done in hospital.
Furosemide sometimes comes mixed with other diuretics or potassium.

Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. 
Furosemide is an anthranilic acid derivative.
Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.
Furosemide mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. 

Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.
The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.

Furosemide is known as a diuretic (like a "water pill"). It helps your body get rid of extra water by increasing the amount of urine you make. Getting rid of extra water decreases the strain on your heart and blood vessels, thereby lowering high blood pressure and reducing your risk of strokes, heart attacks, and kidney problems. 
Furosemide can also improve symptoms such as trouble breathing and swelling (edema). This injectable form of furosemide is used when the drug cannot be taken by mouth, especially in patients with severe medical conditions.

Furosemide can also be used to decrease calcium in the blood (hypercalcemia).

Furosemide is a potent diuretic (water pill) that is used to eliminate water and salt from the body. In the kidneys, salt (composed of sodium and chloride), water, and other small molecules normally are filtered out of the blood and into the tubules of the kidney. The filtered fluid ultimately becomes urine. Most of the sodium, chloride and water that is filtered out of the blood is reabsorbed into the blood before the filtered fluid becomes urine and is eliminated from the body.

Furosemide works by blocking the absorption of sodium, chloride, and water from the filtered fluid in the kidney tubules, causing a profound increase in the output of urine (diuresis).

General description
Furosemide is a an ototoxic high-ceiling diuretic.

Application
Furosemide has been used:
to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

What is furosemide?
Furosemide is a diuretic, which means it helps your body get rid of extra salt (sodium) and water. 
Furosemide works by increasing the amount of urine (pee) you make. 
Furosemide is used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. 
Furosemide can reduce symptoms such as swelling in your ankles or feet, or shortness of breath. 
Furosemide is also used to treat high blood pressure (hypertension).

Furosemide belongs to a group of medicines called loop diuretics. 

Furosemide belongs to a group of drugs called diuretics which increase the amount of urine produced. 
Furosemide is a medicine used in patients with heart and kidney problems to stop fluid building up in the body and so reduce the workload on the heart.

Furosemide helps the body remove excess water by increasing the amount of urine produced. 
Furosemide is often given with a weaker diuretic such as amiloride to prevent excess loss of body salts and potassium. Body salt levels (sodium and potassium) can be affected if a person takes diuretics long term so blood tests may be taken to check levels as required.
Furosemide is used to get rid of extra fluid.
Furosemide is used to treat high blood pressure.

Furosemide is a sulfamoylanthranilic acid derivative, also known as frusemide, and potent loop diuretic. 
Furosemide is widely used to treat hypertension and edema. This agent is highly bound to albumin and is largely excreted unchanged in the urine.
Furosemide is an odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless. 

Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. 
Furosemide is a diuretic used in the treatment of congestive heart failure. 
Furosemide has a role as a xenobiotic, an environmental contaminant and a loop diuretic. 
Furosemide is a sulfonamide, a chlorobenzoic acid and a member of furans.

USES
diuretic antihypertensive    
Diuretics; Sodium Potassium Chloride Symporter Inhibitors
Furosemide has been used empirically and has been legally approved for many years by the US racing industry for the control of exercise-induced pulmonary haemorrhage
MEDICATION (VET)

Chemical properties    
white or white alike crystalline powder. 206 ℃ melting point. Dissolved in acetone, methanol, dimethyl formamide, slightly soluble in ethanol, insoluble in water. Odorless, almost tasteless.

Uses    
The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute renal failure and high blood pressure and other diseases; in combination with fluid infusion, the product can promote poison excretion. Rat oral LD50 is 2600-2820mg/kg.

Uses    
diuretic, antihypertensive
Uses    
Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.
Uses    
This compound belongs to the aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Uses    
An inhibitor of NKCC and a GABAA receptor antagonist.

Clinical Use    
Furosemide has a saluretic effect 8- to 10-fold that of the thiazide diuretics; however, it has a shorter duration of action (~6–8 hours). 
Furosemide causes a marked excretion of sodium, chloride, potassium, calcium, magnesium, and bicarbonate ions, with as much as 25% of the filtered load of sodium excreted in response to initial treatment. 
Furosemide is effective for the treatment of edemas connected with cardiac, hepatic, and renal sites. Because it lowers the blood pressure similar to the thiazide derivatives, one of its uses is in the treatment of hypertension.

Furosemide is a prescription medicine used to treat the symptoms of fluid retention (edema) in individuals with congestive heart failure, liver disease or kidney disorder. 
Furosemide may be used alone or with other medications.

Furosemide belongs to a class of drugs called Diuretics, Loop.

Furosemide is safe and effective in children younger than 1 years of age when used for treatment of resistant hypertension.

Furosemide belongs to a group of medicines called loop diuretics (also known as water pills). 
Furosemide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. 
Furosemide works by acting on the kidneys to increase the flow of urine.

Furosemide is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.
If it continues for a long time, the heart and arteries may not function properly.
Furosemide can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.
High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.