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CAS: 102-76-1
MF: C9H14O6
MW: 218.2
EINECS: 203-051-9
Glycerin triacetate, is the organic compound with the formula C3H5(OCOCH3)3.
Glycerin triacetate is classified as a triglyceride, i.e., the triester of glycerol.
Glycerin triacetate is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point.
Glycerin triacetate has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations.
Glycerin triacetate is one of the glycerine acetate compounds.
Glycerin triacetate also known as glyceryl triacetate, is pharmaceutical excipient used in manufacturing of capsules and tablets, and has been used as a humectant, plasticizer, and solvent.
Glycerin triacetate is a liquid, and has been approved by the FDA as a food additive.
Glycerin triacetate is a water-soluble short-chain triglyceride that may also have a role as a parenteral nutrient according to animal studies.
Glycerin triacetate is also used in the perfume and cosmetic industries.
Glycerin triacetate is a triacetin compound that is used in the production of glycerol and glycerin.
The water vapor-resistant nature of this compound makes Glycerin triacetate an excellent candidate for use in projects where water vapor may be present.
Glycerin triacetate has been shown to have a high resistance to solid phase microextraction and can be used as a model system for studying the interactions of triacetates with other materials.
The reaction solution containing Glycerin triacetate is acidic, which may lead to problems with water permeability if not properly treated.
This analytical method utilizes hydrogen bonding interactions between glycerol and glycerine molecules to measure the concentration of each component in the sample.
Formula: C₉H₁₄O₆
MW: 218.21 g/mol
Boiling Pt: 258 °C (1013 hPa)
Melting Pt: 4 °C
Density: 1.1596 g/cm³ (20 °C)
Flash Pt: 138 °C (closed cup)
Storage Temperature: Ambient
MDL Number: MFCD00008716
CAS Number: 102-76-1
EINECS: 203-051-9
Merck Index: 12,09721
Glycerin triacetate colorless, odorless oily liquid.
Glycerin triacetate is miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil.
Slightly soluble in water.
Uses
Glycerin triacetate is a common food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Glycerin triacetate is used as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.
Glycerin triacetate is an artificial chemical compound, commonly used as a food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Glycerin triacetate is also a component of casting liquor with TG and as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.
Glycerin triacetate can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
In a 1994 report released by five top cigarette companies, Glycerin triacetate was listed as one of the 599 cigarette additives.
Glycerin triacetate is applied to the filter as a plasticizer.
Glycerin triacetate has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
Glycerin triacetate is believed to be safe to get over half of one’s dietary energy from triacetin.
The plasticizing capabilities of Glycerin triacetate have been utilized in the synthesis of a biodegradable phospholipid gel system for the dissemination of the cancer drug paclitaxel (PTX).
In the study, Glycerin triacetate was combined with PTX, ethanol, a phospholipid and a medium chain triglyceride to form a gel-drug complex.
This complex was then injected directly into the cancer cells of glioma-bearing mice.
The gel slowly degraded and facilitated sustained release of PTX into the targeted glioma cells.
Glycerin triacetate can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
Glycerin triacetate has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
Glycerin triacetate is believed to be safe to get over half of one's dietary energy from triacetin.
Glycerin triacetate is used in the following products: adhesives and sealants, coating products, polishes and waxes, washing & cleaning products, perfumes and fragrances, inks and toners, air care products and cosmetics and personal care products.
Other release to the environment of Glycerin triacetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Glycerin triacetate is used in the following products: washing & cleaning products, adhesives and sealants, polishes and waxes and cosmetics and personal care products.
Glycerin triacetate is used in the following areas: health services and formulation of mixtures and/or re-packaging.
Glycerin triacetate is used for the manufacture of: chemicals and .
Other release to the environment of Glycerin triacetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Glycerin triacetate is used in the following products: adhesives and sealants, washing & cleaning products, coating products, inks and toners, cosmetics and personal care products, polymers and perfumes and fragrances.
Glycerin triacetate is used in the following areas: formulation of mixtures and/or re-packaging, health services and building & construction work.
Glycerin triacetate is used for the manufacture of: chemicals and furniture.
Release to the environment of Glycerin triacetate can occur from industrial use: in the production of articles, in processing aids at industrial sites, of substances in closed systems with minimal release, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.
Other release to the environment of Glycerin triacetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Glycerin triacetate is used in the following products: washing & cleaning products, adhesives and sealants, polishes and waxes and cosmetics and personal care products.
Glycerin triacetate is used in the following areas: health services and formulation of mixtures and/or re-packaging.
Glycerin triacetate is used for the manufacture of: chemicals and .
Other release to the environment of Glycerin triacetate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Synthesis
Glycerin triacetate was first prepared in 1854 by the French chemist Marcellin Berthelot.
Glycerin triacetate was prepared in the 19th century from glycerol and acetic acid.
Glycerin triacetate's synthesis from acetic anhydride and glycerol is simple and inexpensive.
3 (CH3CO)2O + 1 C3H5(OH)3 → 1 C3H5(OCOCH3)3 + 3 CH3CO2H
This synthesis has been conducted with catalytic sodium hydroxide and microwave irradiation to give a 99% yield of Glycerin triacetate.
Glycerin triacetate has also been conducted with a cobalt(II) Salen complex catalyst supported by silicon dioxide and heated to 50 °C for 55 minutes to give a 99% yield of triacetin.
Synonyms
triacetin
102-76-1
Glyceryl triacetate
Glycerol triacetate
Enzactin
Glycerin triacetate
Triacetine
Triacetylglycerol
Fungacetin
Glyped
Triacetyl glycerine
Vanay
Kesscoflex TRA
Kodaflex triacetin
1,2,3-Propanetriol, triacetate
1,2,3-triacetoxypropane
Acetin, tri-
propane-1,2,3-triyl triacetate
1,2,3-Propanetriol, 1,2,3-triacetate
Triacetina
Triacetinum
1,2,3-Propanetriol triacetate
Triacetin [INN]
Ujostabil
Estol 1581
FEMA No. 2007
Triacetyl glycerin
Triacetyl glycerol
1,2,3-Propanetriyl triacetate
1,2,3-Triacetylglycerol
2,3-diacetyloxypropyl acetate
Glyceryltriacetate
NSC 4796
Triacetin (USP/INN)
Acetic, 1,2,3-propanetriyl ester
ENZACTIN (TN)
NSC-4796
Ins no.1518
1,2,3-triacetyl-glycerol
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate
Ins-1518
1,2,3-triacetyl-sn-glycerol
CHEBI:9661
XHX3C3X673
E1518
E-1518
NCGC00091612-04
Triacetin (1,2,3-Propanetriol triacetate)
DSSTox_CID_6691
DSSTox_RID_78184
DSSTox_GSID_26691
FEMA Number 2007
Triacetine [INN-French]
Triacetinum [INN-Latin]
Triacetina [INN-Spanish]
CAS-102-76-1
HSDB 585
EINECS 203-051-9
TRIACETIN (GLYCEROL TRIACETATE)
BRN 1792353
Triacetin [USP:INN:BAN]
UNII-XHX3C3X673
Enzacetin
Euzactin
Fungacet
Motisil
Blekin
tri-acetin
AI3-00661
CCRIS 9355
Triacetin, CP
Triacetin, FCC
Triacetin, USP
3-Triacetoxypropane
Glycerine triacetate
MFCD00008716
Triacetin, 99%
Spectrum_000881
TRIACETIN [FCC]
TRIACETIN [II]
TRIACETIN [MI
TRIACETIN [FHFI]
TRIACETIN [HSDB]
TRIACETIN [INCI]
Spectrum2_000939
Spectrum3_001368
Spectrum4_000362
Spectrum5_001376
TRIACETIN [VANDF]
TRIACETIN [MART.]
EC 203-051-9
Triacetin, >=99.5%
SCHEMBL3870
TRIACETIN [USP-RS]
TRIACETIN [WHO-DD]
BSPBio_002896
Glycerol triacetate tributyrin
KBioGR_000823
KBioSS_001361
4-02-00-00253 (Beilstein Handbook Reference)
MLS002152946
1,3-Propanetriol, triacetate
DivK1c_000740
Glyceryl triacetate, >=99%
SPECTRUM1500585
Triacetin, analytical standard
SPBio_000878
Triacetin, 99%, FCC, FG
1,2,3-propanediol triethanoate
CHEMBL1489254
DTXSID3026691
TRIACETIN [EP MONOGRAPH]
FEMA 2007
HMS502E22
KBio1_000740
KBio2_001361
KBio2_003929
KBio2_006497
KBio3_002116
NSC4796
TRIACETIN [USP MONOGRAPH]
NINDS_000740
HMS1921G05
HMS2092O09
HMS2232I22
Pharmakon1600-01500585
Triacetin, >=99%, natural, FG
HY-B0896
ZINC1530705
Tox21_111155
Tox21_201745
Tox21_300111
WLN: 1VO1YOV1 & 1OV1
CCG-39680
LMGL03012615
NSC757364
s4581
Triacetin, 8CI, BAN, INN, USAN
1,2,3-Propanetriol triacetate, 9CI
AKOS009028851
Tox21_111155_1
Glyceryl triacetate, >=99.0% (GC)
NSC-757364
1,3-bis(acetyloxy)propan-2-yl acetate
IDI1_000740
NCGC00091612-01
NCGC00091612-02
NCGC00091612-03
NCGC00091612-05
NCGC00091612-06
NCGC00091612-07
NCGC00091612-09
NCGC00254207-01
NCGC00259294-01
LS-13668
SMR001224538
SBI-0051540.P002
FT-0626753
G0086
EN300-19216
D00384
E 1518
E75962
Q83253
AB00052112_06
A800614
SR-05000002079
J-000781
SR-05000002079-1
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate #
Z104473192
Triacetin, GTA F.G (1,2,3-PROPANETRIOL TRIACETATE)
Triacetin, United States Pharmacopeia (USP) Reference Standard
Triacetin, Pharmaceutical Secondary Standard; Certified Reference Material
1,2,3-Propanetriol triacetate; Glycerol Triacetate, USP Grade(1.03000); TRIACETINE; Glycerol triacetate; Glyceryl triacetate; propane-1,2,3-triyl triacetate
