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Diglycine = Glycyl-Glycine = Glycylglycine
CAS: 556-50-3
European Community (EC) Number: 209-127-8
Molecular Formula: C4H8N2O3
Molecular Weight: 132.12
IUPAC Name: 2-[(2-aminoacetyl)amino]acetic acid
Boiling Point: 453.24°C at 760.00mmHg
Melting Point: 215°C
Solubility: 166 mg/mL at 21 °C
Glycylglycine is the dipeptide of glycine, making it the simplest peptide.
Glycylglycine was first synthesized by Emil Fischer and Ernest Fourneau in 1901 by boiling 2,5-diketopiperazine (glycine anhydride) with hydrochloric acid.
Shaking with alkali and other synthesis methods have been reported.
Because of its low toxicity, glycylglycine is useful as a buffer for biological systems with effective ranges between pH 2.5–3.8 and 7.5–8.9; however, it is only moderately stable for storage once dissolved.
Glycylglycine is used in the synthesis of more complex peptides.
Glycylglycine has also been reported to be helpful in solubilizing recombinant proteins in E. coli.
Using different concentrations of the glycylglycine improvement in protein solubility after cell lysis has been observed.
Glycylglycine (Gly-Gly) is a dipeptide used in biochemical research.
Glycylglycine is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides.
Glycylglycine is also useful as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C).
Glycylglycine is valuable agent for experiments investigating peptide transport and absorption.
Glycylglycine (Glygly) is a low toxicity peptide.
In the biotech industry, Glygly is used as a buffer for biological systems especially in solubilizing proteins, liposomes, nanotubes and other macromolecules.
In the cosmetics market, Glygly emulsifying property is commercialized in various moisturizing hair care sprays for smooth, soft, supple hair.
Moreover, Glygly is also marketed as topical skin care products to tighten conspicuous facial pores by alleviating roughness around pores formed from excessive skin oil and dryness.
Glycylglycine is the dipeptide of glycine, making it the simplest peptide.
The compound was first synthesized by Emil Fischer and Ernest Fourneau in 1901 by boiling 2,5-diketopiperazine (glycine anhydride) with hydrochloric acid.
Shaking with alkali and other synthesis methods have been reported.
Because of its low toxicity, Glycylglycine is useful as a buffer for biological systems with effective ranges between pH 2.5–3.8 and 7.5–8.9; however, it is only moderately stable for storage once dissolved.
Glycylglycine is used in the synthesis of more complex peptides.
Glycylglycine has also been reported to be helpful in solubilizing recombinant proteins in E. coli.
Using different concentrations of the glycylglycine improvement in protein solubility after cell lysis has been observed. (
Glycylglycine is a dipeptide formed from glycine residues.
Glycylglycine has a role as a human metabolite.
Glycylglycine derives from a glycine.
Glycylglycine is a tautomer of a glycylglycine zwitterion.
Glycylglycine is the simplest of all peptides.
Glycylglycine functions as a gamma-glutamyl acceptor.
Glycylglycine is as a buffering reagent and also used in biochemical research.
Glycylglycine is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides.
Glycylglycine is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C).
Valuable agent for experiments investigating peptide transport and absorption.
Use Glycylglycine as a buffer in diagnostic reagents, or as a substrate in γ-glutamyltransferase tests where γ-glutamyltransferase transfers the gamma-glutamyl group of L-γ-glutamyl-3-carboxy-4-nitroanilide (Glupa-C) to glyclglycine.
Uses of Glycylglycine Buffer:
-Glycylglycine is a dipeptide also used as a buffering agent in enzymatic assays and in medical procedures.
-Used in ion exchange chromatography.
-Used as a lysis buffer, running buffer and an enzymatic reaction buffer.
-Used in cosmetics as a moisturizer and inflammation inhibitor for skin care products
Applications
Glycylglycine is as a buffering reagent and also used in biochemical research.
Glycylglycine is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides.
Glycylglycine is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C).
Valuable agent for experiments investigating peptide transport and absorption.
SYNONYMS:
Glycylglycine
556-50-3
Diglycine
N-GLYCYLGLYCINE
Gly-Gly
Glycine, glycyl-
Glycyl-glycine
Glycine dipeptide
2-(2-Aminoacetamido)Acetic Acid
Glycine, N-glycyl-
2-[(2-aminoacetyl)amino]acetic acid
Gly2
Gly-Gly-OH
H-Gly-Gly-OH
Glycyl Glycine
2-(Aminoacetamido)acetic acid
alpha-Glycylglycine
Diglycine (VAN)
[(Aminoacetyl)amino]acetic acid
UNII-10525P22U0
MFCD00008130
CHEMBL292467
CHEBI:17201
[(ammonioacetyl)amino]acetate
2-(2-azanylethanoylamino)ethanoic acid
10525P22U0
((aminoacetyl)amino)acetic acid
Glycylglyine
Glycylgycine
Dipeptide-15
GG0
EINECS 209-127-8
H-Gly-Gly
Glycylglycine, DL-
NSC 49346
.alpha.-Glycylglycine
n-GLYCYL- Glycine
ACMC-1AWKP
AI3-62521
Glycylglycine (GLYGLY)
Gly-Gly, 98%
B-GLYGLY250
SCHEMBL14934
DTXSID90862194
Gly-Gly, >=99% (titration)
[(Aminoacetyl)amino]acetic acid #
AMY25302
HY-D0889
NSC49346
ZINC5112515
BBL018705
BDBM50169222
NSC-49346
s4810
STL194277
AKOS001045997
CCG-231053
MCULE-1239116894
Gly-Gly, BioXtra, >=99.0% (NT)
AS-14771
BP-31104
Gly-Gly, BioUltra, >=99.5% (NT)
M541
SY018005
Gly-Gly, Vetec(TM) reagent grade, 99%
AB0006830
DB-002742
CS-0015211
FT-0626788
G0124
C02037
F17229
G-6000
G-6001
Glycylglycine, 0.2M buffer solution, pH 8.0
Glycylglycine, 0.2M buffer solution, pH 8.5
556G503
Q665455
F2191-0195
33903968-DDB2-47F2-9B6C-7C232D1962DA
Dyglycine, United States Pharmacopeia (USP) Reference Standard
Gly-Gly, BioPerformance Certified, cell culture tested, >=99%
2-[(2-Aminoacetyl)amino]acetic Acid (Diglycine; N-Glycylglycine)
GlycylGlycine, PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production
