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An L-Arginine that is the L-isomer of arginine.
L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction.
L-Arginine is a key precursor for synthesizing nitric oxide in mammals.
CAS: 74-79-3
MF: C6H14N4O2
MW: 174.2
EINECS: 200-811-1
Synonyms
ABL2 (38-end), active, His tagged human;FLJ41441;ANTI-ABL2 antibody produced in mouse;FLJ22224;FLJ31718;Abelson murine leukemia viral oncogene homolog 2;Abelson tyrosine-protein kinase 2;ABL2
Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits.
L-arginine is an amino acid that helps the body build protein.
Your body usually makes all the L-arginine it needs.
L-arginine is also found in most protein-rich foods, including fish, red meat, poultry, soy, whole grains, beans and dairy products.
As a supplement, L-arginine can be used orally and topically.
L-Arginine can also be administered intravenously (IV).
L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction.
L-Arginine is a key precursor for synthesizing nitric oxide in mammals.
Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits.
L-Arginine is a nonessential amino acid that is an important precursor for the synthesis of proteins.
L-Arginine is also involved in the metabolism of nitric oxide, and may be cardioprotective by preventing myocardial infarcts.
L-Arginine is synthesized from citrulline by methylation, which can be inhibited by erythromycin.
This inhibition leads to accumulation of l-arginine with subsequent downstream effects on polymerase chain reaction (PCR) and DNA synthesis.
L-Arginine may also have a role in energy metabolism as it participates in the dinucleotide L-Arginine is an alpha-amino acid that is classified as semi-essential in humans.
L-Arginine is used in the biomanufacturing of recombinant proteins and monoclonal antibodies.
L-Arginine is an important constituent in cell culture media.
Odorless, slightly bitter.
Easily soluble in water (solubility in 0℃ water is 83g/L, solubility in 50℃ water is 400g/L), very slightly soluble in ethanol, insoluble in ether; pI6.0; loses its 2-molecule water crystal when heated to 105℃, darkens in color at 230℃, disintegrates at 244℃; its aqueous solution has maximum absorption at 205nm (1gε3.28).
L-Arginine is an encoding amino acid in protein synthesis and is one of the 8 essential amino acids in the human body.
The body needs L-Arginine for many different functions.
Taking L-Arginine supplements can treat certain diseases such as congestive heart failure and cystitis.
L-Arginine can also act as seasoning for nutrient supplements and food additives.
L-Arginine can undergo a heat reaction with sugar (amino-carbonyl reaction) to obtain a unique fragrance, GB 2760-2001, an approved food spice.
As an amino acid drug, L-Arginine can be used as pharmaceutical raw material and is an important ingredient in amino acid infusions and integrated amino acid preparations.
L-Arginine is also a crucial amino acid in maintaining infant growth and maturation.
L-Arginine Chemical Properties
Melting point: 222 °C (dec.) (lit.)
Alpha: 27.1 º (c=8, 6N HCl)
Boiling point: 305.18°C (rough estimate)
Density: 1.2297 (rough estimate)
Bulk density: 640kg/m3
Refractive index: 27 ° (C=8, 6mol/L HCl)
FEMA: 3819 | L-ARGININE
Storage temp.: 2-8°C
Solubility: H2O: 100 mg/mL
Form: powder
pka: 1.82, 8.99, 12.5(at 25℃)
Color: white
PH: 10.5-12.0 (25℃, 0.5M in H2O)
PH Range: 10.5 - 12
Odor: Faint
Odor Type: bland
Biological source: synthetic
Optical activity: [α]20/D +27°, c = 8 in 6 M HCl
Water Solubility: 148.7 g/L (20 ºC)
Sensitive: Air Sensitive
λmax λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Merck: 14,780
JECFA Number: 1438
Specific Activity: 1035-1401nmol/min·mg
BRN: 1725413
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey: ODKSFYDXXFIFQN-BYPYZUCNSA-N
LogP: -4.20
CAS DataBase Reference: 74-79-3(CAS DataBase Reference)
NIST Chemistry Reference: L-Arginine(74-79-3)
EPA Substance Registry System: L-Arginine (74-79-3)
L-Arginine is a diaminomonocarboxylic acid.
The nonessential amino acid, arginine, is a urea cycle amino acid and a precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction of small blood vessels.
L-Arginine is strongly alkaline and its water solutions absorb carbon dioxide from the air.
Functionality in foods includes, but is not limited to, nutrient and dietary supplement
Mechanisms of Action
L-Arginine can stimulate the human body to release certain chemicals such as insulin and human growth hormone.
L-Arginine can also clear ammonia in the body and promote the healing of wounds.
The human body also needs it to produce sarcosine.
Decomposing L-Arginine produces nitric oxide, which can expand blood vessels and increase blood flow.
L-Arginine is an intermediate metabolite in the orthinine cycle and promotes the conversion of ammonia to urea, thus lowering the blood concentration of ammonia.
L-Arginine is also an important part of sperm protein and can promote spermatogenesis and provide energy for sperm movement.
Additionally, intravenous arginine can stimulate the pituitary to release growth hormone and can be used to test pituitary functions.
Uses
L-Arginine is used for heart and blood vessel conditions which includes congestive heart failure (CHF), chest pain, high blood pressure and coronary artery disease.
L-Arginine plays a vital role in the treatment of cardiovascular disease due to it being antiatherogenic, anti-ischemic, antiplatelet and antithrombotic.
L-Arginine acts as a growth stimulant and is involved in the treatment of erectile dysfunction in men.
L-Arginine is an important ingredient of tooth paste which provides effective relief for sensitive teeth.
L-Arginine has been used:
as a Roswell park memorial institute medium (RPMI) media component in the isolation and culture of peripheral blood mononuclear cells (PBMCs)
as a RPMI media component for tissue culture
in DMEM medium for the identification and quantification of phosphorylation sites by stable isotope labeling by amino acids in cell culture (SILAC) and LCMS/MS
Synthesis
Enzymatically, arginine is formed in two reactions from citrulline.
The first reaction (citrulline + succinate) is catalyzed by the enzyme arginosuccinate synthetase.
L-Arginine is ATP dependent and with the formation of a new C–N bond in the gaunidino group of arginosuccinate, water is removed and ATP is hydrolyzed.
The second reaction is catalyzed by arginine synthetase and involves the scission of arginosuccinate with the formation of arginine and fumaric acid.
