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Macleaya cordata extract is a green pollution-free plant extract.
Macleaya cordata extract contains several alkaloids including sanguinarine,chelerythrine, protopine, and allocryptopine.
Macleaya cordata extracts are the main components of it, which have fungicidal and insecticidal activity.
CAS Number: 112025-60-2
Molecular Formula: C41H32Cl2N2O8
Moecular Weight: 751.61
Synonyms:112025-60-2, Chelerythrine chloride mixt. with sanguinarine chloride, Sanguinarine chloride mixt. with chelerythrine chloridechelerythrine chloride-sanguinarine chloride mixt.;Macleaya cordata extract;13-Methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride mixt. with 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;MACLEAYA EXTRACT;Plumepoppy P.E.;sanguinarine chloride, sanguinarine;Plumepoppy Extract;Pink Plumepoppy,Plume-poppy,Tree celandine
Macleaya cordata extract is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
Macleaya cordata extract was been shown to be reversible inhibitors of the enzymatic hydrolysis of acetylthiocholine.
Macleaya cordata extract, registered under the name of the fungicide Qwel (Camas Technologies Inc.), induces increased amounts of polyphenolic phytoalexines, as well as systemic acquired resistance.
Macleaya cordata extract is derived from the plant Macleaya cordata, also known as plume poppy.
This plant is native to East Asia, particularly China and Japan, and belongs to the poppy family (Papaveraceae).
Macleaya cordata extract of Macleaya cordata is used primarily for its bioactive alkaloids, which have been found to possess various medicinal properties.
Macleaya cordata extract is a bloodroot which owns thousand year history of medicinal usage in China.
Macleaya cordata extract and other compounds such as sanguinarine, toddaline, protopine, a-allocryptopine, bocconine, rhizoma coptidis alkali, berberine, samin alkali and protopine are in the root and aerial parts.
Macleaya cordata extract contains sanguinaine and chelerythrine, which have fungicidal and insecticidal activity.
Macleaya cordata extract is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
Macleaya cordata contains several alkaloids including sanguinarine, chelerythrine, protopine, and allocryptopine.
Macleaya cordata extract mainly constains with sanguinarine and chelerythrine.
It was been show to be reversible inhibitors of the enzymatic hydrolysis of acetylthiocholine.
A benzylisoquinoline alkaloid known for its antimicrobial and anti-inflammatory properties.
Another alkaloid that has potent biological activities, including anti-inflammatory and antioxidant effects.
Macleaya cordata extract has a long history of use in traditional Chinese medicine, and today it is used in both natural medicine and commercial products for various purposes:
Macleaya cordata extract, one of the key alkaloids in Macleaya cordata, exhibits strong antimicrobial properties.
It is used in natural remedies to combat bacterial and fungal infections, making it a common ingredient in topical treatments for skin conditions like acne or fungal infections.
It may also be included in personal care products, such as toothpaste and mouthwash, for its ability to reduce oral bacteria and plaque formation.
Macleaya cordata extract is widely used for its anti-inflammatory effects, helping to reduce swelling and inflammation.
It may be applied topically to soothe skin irritations, minor wounds, or inflammatory skin conditions like eczema or psoriasis.
Some supplements containing Macleaya cordata are marketed for their potential to alleviate inflammatory conditions internally, though these claims should be used with caution.
Macleaya cordata extract, particularly because of its alkaloid content, is sometimes used in natural pesticides due to its ability to act as a deterrent against pests.
Its potent alkaloids can disrupt the nervous system of insects, making it an effective biological control agent in agriculture.
Due to its antibacterial and anti-inflammatory properties, Macleaya cordata extract is often applied topically to aid in wound healing, promote skin regeneration, and prevent infections.
Some cosmetic and skin care products incorporate the extract to enhance skin health and improve texture.
The alkaloids found in Macleaya cordata extract exhibit antioxidant properties, which may help protect cells from oxidative damage caused by free radicals.
This has potential applications in anti-aging skincare products, where reducing oxidative stress is key to preventing premature aging.
Early research on Macleaya cordata extract and chelerythrine has shown some potential anticancer effects, particularly in laboratory settings.
These alkaloids have been found to induce apoptosis (programmed cell death) in certain cancer cells, although much more research is needed before the extract can be widely used for this purpose.
Some herbal supplements containing Macleaya cordata extract claim to support the immune system, primarily due to its antimicrobial and anti-inflammatory actions.
Macleaya cordata extract is believed to help boost the body’s defense mechanisms against infections.
In animal husbandry, Macleaya cordata extract is sometimes added to animal feed as a natural growth promoter and to improve gut health.
Its antibacterial properties may help reduce harmful bacteria in the digestive system of livestock, promoting healthier growth without the use of antibiotics.
Although Macleaya cordata extract has many beneficial properties, it also poses some risks, especially when consumed internally or used improperly.
The key alkaloids, sanguinarine and chelerythrine, are potent compounds that can have toxic effects at high concentrations.
Both of these alkaloids are considered toxic at high doses and may cause adverse reactions.
Ingesting large amounts of the Macleaya cordata extract can lead to nausea, vomiting, or more severe effects like liver damage.
Some studies have raised concerns that sanguinarine might have carcinogenic effects, especially when used in high doses or over long periods, though more research is needed to confirm this.
When applied topically, Macleaya cordata extract can cause irritation or allergic reactions in sensitive individuals, particularly if used in high concentrations.
Internal consumption of Macleaya cordata extract is generally not recommended without supervision, as the alkaloids can be toxic to the liver and other organs at high doses.
Macleaya cordata extract is primarily used in topical applications or controlled doses in supplements for specific purposes.
There is not enough reliable information on the safety of using Macleaya cordata during pregnancy or breastfeeding.
Therefore, Macleaya cordata extract is best to avoid using it during these periods unless under medical supervision.
As with many herbal extracts, Macleaya cordata extract could potentially interact with medications, particularly those that affect liver enzymes or immune function.
Uses:
Macleaya cordata extract can be widely used in feed additive, bacteriostatic agent, pesticides, veterinary drugs, disinfectant, etc.
Macleaya cordata extract has effect on detoxifying and eliminating swelling.
It can improve the liver function and incrase immunity.
It has the function of anti-inflammatory, anti-bacterial and antiviral.
Macleaya cordata extract has the function of insecticide, to some extent, it can effectively inhibit bacteria and fungi.
Macleaya cordata extract, particularly for its key alkaloid sanguinarine, is used in oral care products like toothpaste and mouthwash to reduce oral bacteria, plaque formation, and gum inflammation.
It is used in topical formulations to treat minor skin infections, acne, and fungal conditions due to its antimicrobial properties.
Applied topically, Macleaya cordata extract can help soothe inflammatory skin conditions such as eczema and psoriasis, reducing redness and swelling.
Macleaya cordata extract is sometimes used in creams or supplements for managing symptoms of arthritis and other inflammatory joint disorders.
Macleaya cordata extract is utilized in natural pesticides and insecticides.
Its alkaloids act as deterrents against various pests and insects, providing a less toxic alternative to synthetic chemicals.
Due to its antimicrobial and anti-inflammatory effects, Macleaya cordata extract is applied to wounds and minor cuts to promote faster healing and reduce the risk of infection.
Macleaya cordata extract’s antioxidant properties make it a valuable ingredient in skincare products aimed at reducing oxidative stress, preventing premature aging, and protecting the skin from environmental damage.
In dietary supplements, the extract is sometimes used to support the immune system due to its antimicrobial and anti-inflammatory effects.
Macleaya cordata extract is added to animal feed as a natural growth promoter and to improve gut health.
It helps in reducing harmful bacteria in the digestive systems of livestock.
In traditional medicine, particularly in China, Macleaya cordata extract has been used for its various health benefits, including as a remedy for coughs and respiratory issues.
It is incorporated into lotions, creams, and serums for its anti-inflammatory and antimicrobial properties, benefiting skin health and appearance.
Some studies have explored the potential anticancer properties of Macleaya cordata extract, particularly the alkaloids sanguinarine and chelerythrine, which may induce apoptosis (cell death) in cancer cells.
However, this use is still under investigation and not yet established in clinical practice.
There is emerging interest in the antiviral properties of the extract, though more research is needed to confirm its effectiveness in treating viral infections.
Safety Profile:
The main alkaloids in Macleaya cordata extract, particularly sanguinarine and chelerythrine, can be toxic at high doses.
They can cause adverse effects such as nausea, vomiting, and, in severe cases, liver damage or other systemic toxicity if ingested in large amounts.
Some studies suggest that sanguinarine might have carcinogenic effects, particularly with long-term or high-dose exposure.
More research is needed to fully understand these risks.
When applied to the skin, Macleaya cordata extract can cause irritation or allergic reactions in some individuals.
This may include redness, itching, or a rash, particularly in sensitive individuals or when used in high concentrations.
