TYLOSE MHS ​​150003 P4

TYLOSE MHS 150003 P4

Tylose MHS 150003 P4 is a commonly used cellulose ethers organic water-based ink thickening agent, belongs to a water-soluble non-ionic compound, with good water thickening ability, degraded by oxygen, acid and enzyme, under alkaline conditions can be crosslinked by Cu2 +.

CAS NO : 9004-62-0
EC NO :618-387-5

IUPAC NAME 
5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol

SYNONYMS

Hetastarch
9004-62-0
Hespan
5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
Plasmasteril
Pentaspan
Hespander
Onkohas
Voluven
Hespander injection
HAS [German]
Penford 260
Penford 280
Penford 290
Ethylex gum 2020
Penford P 208
Essex gum 1360
Essex 1360
Hetastarch [USAN:BAN]
Pentastarch [USAN:BAN]
O-(2-Hydroxyethyl)starch
Hydroxyathylstarke [German]
2-Hydroxyethyl starch ether
Starch 2-hydroxyethyl ether
Tapioca starch hydroxyethyl ether
ASL 607
DTXSID60873934
VZ36173
LS-146657
FT-0627136
2-O-(2-Hydroxyethyl)-4-O-methylhexopyranosyl-(1->4)-[4-O-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol
2-hydroxyethylcelluloseether;ah15;aw15(polysaccharide);aw15[polysaccharide];bl15;cellosize;The blood coHydroxyethyl cellulose etherngeals the appearance board;5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
HYPROMELLOSE
Hydroxypropyl Methylcellulose
K100M USP Grade
9004-65-3 Active CAS-RN
Cellulose, 2-hydroxypropyl methyl ether
2-Hydroxypropyl methyl cellulose
2-Hydroxypropyl methyl cellulose ether
2-Hydroxypropyl cellulose methyl ether
Hydroxypropylmethylcellulosum
Isopto alkaline
Isopto plain
Isopto Tears
Methocel E,F,K,
Methyl cellulose, propylene glycol ether
Methylhydroxypropylcellulosum
Metolose
Tearisol
Hipromelosa
Hypromellosum
Hydroxypropyl methyl cellulose (464)
cellulose hydroxypropyl methyl ether
cellulose,
2-hydroxypropyl methyl ether
2-hydroxypropyl cellulose methyl ether
2-hydroxypropyl methyl cellulose
hydroxypropyl methylcellulose
hydroxypropylmethyl cellulose
hydroxypropylmethylcellulose
hydroxypropylmethylcellulosum
methyl cellulose,
propylene glycol ether
methyl hydroxypropyl cellulose
methylhydroxypropylcellulose
methylhydroxypropylcellulosum
E464, hydroxypropyl methylcellulose, HPMC
hypromellose(noun)
Hydroxypropyl methylcellulose,

TYLOSE MHS 150003 P4

Thickeners and binders
TYLOSE MHS 150003 P4 is a commonly used cellulose ethers organic water-based ink thickening agent, belongs to a water-soluble non-ionic compound, with good water thickening ability, degraded by oxygen, acid and enzyme, under alkaline conditions can be crosslinked by Cu2 +. Has thermal stability, when heated, does not appear gelation, does not occur precipitation under acidic conditions, the film-forming property is good, the aqueous solution can be made of a transparent film, can be derived from the reaction of alkali cellulose with ethylene oxide, having properties such as thickening, emulsifying, adhesive, suspension, film-forming, maintaining moisture and protectiving colloid. The role of thickener in the aqueous ink is thickened. The viscosity of the ink added a thickening agent increases, can improve the physical and chemical stability of the ink; due to the increased viscosity, rheology of the ink can be controlled at the time of printing; the pigment and filler in ink is not easy to precipitate, increasing the storage stability of the water-based ink.
Thickening agent is a cellulose-based material and (or) polyvinyl alcohol substances. Cellulose substances may be methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose; polyvinyl alcohol material may be an or several species of polyethylene 400, 600, 800, 1000, 1600, 2000, 4000, 6000.

Chemical properties
This product is white to yellowish fibrous or powdery solid, non-toxic, tasteless and soluble in water. Insoluble in common organic solvents. Having properties such as thickening, suspending, adhesive, emulsifying, dispersing, water holding. Different viscosity range of solution can be prepared. Having exceptionally good salt solubility to electrolyte.

Uses    
1. TYLOSE MHS 150003 P4 is used for cracking method to extract polymerized dispersing agents such as oil water base gel fracturing fluid, polystyrene and polyvinyl chloride. Also for latex thickening agent in paint industry, hygristor in electronics industry, cement anti-coagulant agent and water retention agent in construction industry. Glazing in ceramic industry and toothpaste binder. Also widely used in many aspects such as printing and dyeing, textile, paper, pharmaceutical, health, food, cigarettes, pesticides and fire extinguishing agent.
2. Used as a water-based drilling fluids, and thickening agent and filtrate reducer of completion fluids, thickening agent has obvious effect on brine drilling fluid. Also can be used for filtrate reducer of oil well cement. Cross-linking with the polyvalent metal ions into a gel.
3. As surfactants, protective colloids, emulsion stabilizers in combination with emulsion such as vinyl chloride, vinyl acetate emulsion, and a tackifier, dispersant, dispersion stabilizer of emulsion. Widely used in many aspects such as coatings, fibers, dyeing, paper, cosmetics, pharmaceuticals, pesticides. There are many uses in oil exploitation and machinery industry.
4. As surfactants, latex thickening agent, protective colloid, oil exploitation fracturing fluid and polystyrene and polyvinyl chloride dispersing agents, etc.
Production methods    
1. Alkali cellulose is a natural polymer, each of a fiber-based ring contains three hydroxyl groups, the most active hydroxyl reaction to give  Tylose MHS 150003 p4. The raw material cotton linter or refined pulp meal were immersed in 30% liquid caustic soda, took out to squeeze after half an hour. Squeezed water containing soda to 1: 2.8, pulverized. Pulverized alkali cellulose was added into the reaction kettle, sealed, vacuumized, nitrogen charge, repeated to vacuumize and nitrogen charge to replace atmosphere in the reaction kettle. Precooled the liquid ethylene oxide was pressed into, cooling water was pumped in jacket of reaction kettle, controlled at about 25 ℃ and reacted for 2 h, crude product of Tylose MHS 150003 p4. was obtained. The crude product was washed with alcohol, added acetic acid to adjust pH value to 4-6, added glyoxal to crosslink and aging. Then washed with water, centrifugal dewatering, dryed, milled to obtain  Tylose MHS 150003 p4. Raw material consumption (kg/t) linter or low pulp meal 730-780 liquid caustic soda (30%) 2400 ethylene oxide 900 alcohol (95%) 4500 acetic acid 240 Glyoxal (40%) 100-300.
2. The raw material cotton linter or refined pulp meal were immersed in 30% liquid caustic soda, after half an hour took out to squeeze. Squeezed water containing soda to 1: 2.8, pulverized alkali cellulose was added into the reaction kettle, sealed and vacuumized, nitrogen charge, used nitrogen to replace all atmosphere in the reaction kettle,Precooled the liquid ethylene oxide was pressed into. In the cooling, controlled at 25 ℃ and reacted for 2 h, to give the crude product of crude  Tylose MHS 150003 p4. The crude product was washed with ethanol and acetic acid was added to adjust the pH value to 4-6. added glyoxal to crosslink and aging, washed with water fast, finally centrifugal dehydration, dried, milled, obtained low salt Tylose MHS 150003 p4.
Description
Hetastarch, another nonproteinaceous colloid, is a complex mixture of ethoxylated amylopectins ranging in molecular weight from 10 to 1,000 kDa (average molecular weight, ~450 kDa). When infused as a 6% solution, hetastarch approximates the activity of human albumin. The larger molecular weights, however, increase its intravascular residence time as well as its plasma expansion effects relative to albumin.
Hetastarch is synthetically produced, so it is degraded more slowly and is less antigenic than other colloids. Despite these advantages, hetastarch is quite expensive and also has no oxygen-carrying capacity.
Chemical Properties
light yellow powder
Chemical Properties
TYLOSE MHS 150003 P4  occurs as a white, yellowish-white or grayish-white, odorless and tasteless, hygroscopic powder.
Uses    
TYLOSE MHS 150003 P4 is a thickener, protective colloid, binder, stabilizer, and suspending agent. It is obtained from wood pulp Copyright 2014 Cengage Learning. All Rights Reserved. May not be copied, scanned, or duplicated, in whole or in part. Due to electronic rights, some third party content may be suppressed from the eBook and/or eChapter(s). Editorial Review has deemed that any suppressed content does not materially affect the overall learning experience. Cengage Learning reserves the right to remove additional content at any time if subsequent rights restrictions require it. or chemical cotton by treatment with an alkali.
Pharmaceutical Applications
TYLOSE MHS 150003 P4  is a nonionic, water-soluble polymer widely used in pharmaceutical formulations. It is primarily used as a thickening agent in ophthalmic and topical formulations, although it is also used as a binder and film-coating agent for tablets.It is present in lubricant preparations for dry eye, contact lens care, and dry mouth.
The concentration of TYLOSE MHS 150003 P4 used in a formulation is dependent upon the solvent and the molecular weight of the grade.
TYLOSE MHS 150003 P4 is also widely used in cosmetics.
storage    
TYLOSE MHS 150003 P4 powder is a stable though hygroscopic material.
Aqueous solutions of hydroxyethyl cellulose are relatively stable at pH 2–12 with the viscosity of solutions being largely unaffected. However, solutions are less stable below pH 5 owing to hydrolysis. At high pH, oxidation may occur.
Increasing the temperature reduces the viscosity of aqueous TYLOSE MHS 150003 P4 solutions. However, on cooling, the original viscosity is restored. Solutions may be subjected to freeze–thawing, high-temperature storage, or boiling without precipitation or gelation occurring.
TYLOSE MHS 150003 P4 is subject to enzymatic degradation, with consequent loss in viscosity of its solutions. Enzymes that catalyze this degradation are produced by many bacteria and fungi present in the environment. For prolonged storage, an antimicrobial preservative should therefore be added to aqueous solutions. Aqueous solutions of TYLOSE MHS 150003 P4 may also be sterilized by autoclaving.
TYLOSE MHS 150003 P4 powder should be stored in a well-closed container, in a cool, dry place.

Incompatibilities
TYLOSE MHS 150003 P4  is insoluble in most organic solvents. It is incompatible with zein and partially compatible with the following water-soluble compounds: casein; gelatin; methylcellulose; polyvinyl alcohol, and starch.
TYLOSE MHS 150003 P4  can be used with a wide variety of watersoluble antimicrobial preservatives. However, sodium pentachlorophenate produces an immediate increase in viscosity when added to hydroxyethyl cellulose solutions.
TYLOSE MHS 150003 P4  has good tolerance for dissolved electrolytes, although it may be salted out of solution when mixed with certain salt solutions. For example, the following salt solutions will precipitate a 10% w/v solution of Cellosize WP-09 and a 2% w/v solution of Cellosize WP-4400: sodium carbonate 50% and saturated solutions of aluminum sulfate; ammonium sulfate; chromic sulfate; disodium phosphate; magnesium sulfate; potassium ferrocyanide; sodium sulfate; sodium sulfite; sodium thiosulfate; and zinc sulfate.
Natrosol is soluble in most 10% salt solutions, excluding sodium carbonate and sodium sulfate, and many 50% salt solutions with the exception of the following: aluminum sulfate; ammonium sulfate; diammonium phosphate; disodium phosphate; ferric chloride; magnesium sulfate; potassium ferrocyanide; sodium metaborate; sodium nitrate; sodium sulfite; trisodium phosphate; and zinc sulfate. Natrosol 150 is generally more tolerant of dissolved salts than is Natrosol 250.
TYLOSE MHS 150003 P4  is also incompatible with certain fluorescent dyes or optical brighteners, and certain quaternary disinfectants which will increase the viscosity of aqueous solutions.
Information on basic physical and chemical properties
TYLOSE MHS 150003 P4 Physical state : Solid
TYLOSE MHS 150003 P4 Appearance : Powder.
TYLOSE MHS 150003 P4 Colour : whitish.
TYLOSE MHS 150003 P4 Odour : Odourless.
TYLOSE MHS 150003 P4 Odour threshold : No data available
TYLOSE MHS 150003 P4 pH : 6 - 8 10g/l
TYLOSE MHS 150003 P4 Relative evaporation rate (butylacetate=1) : Not specifically applicable
TYLOSE MHS 150003 P4 Melting point : Not specifically applicable
TYLOSE MHS 150003 P4 Freezing point : Not specifically applicable
TYLOSE MHS 150003 P4 Boiling point : Not specifically applicable
TYLOSE MHS 150003 P4 Flash point : Not specifically applicable
TYLOSE MHS 150003 P4 Auto-ignition temperature : > 170 °C
TYLOSE MHS 150003 P4 Decomposition temperature : No data available
TYLOSE MHS 150003 P4 Flammability (solid, gas) : No data available
TYLOSE MHS 150003 P4 Vapour pressure : Not specifically applicable
TYLOSE MHS 150003 P4 Vapour pressure at 50 °C : Not specifically applicable
TYLOSE MHS 150003 P4 Relative vapour density at 20 °C : Not specifically applicable
TYLOSE MHS 150003 P4 Relative density : Not specifically applicable
TYLOSE MHS 150003 P4 Density : 1.1 - 1.5 g/cm³ 20 °C
TYLOSE MHS 150003 P4 Solubility : Water: > 10 g/l @ 20°C
TYLOSE MHS 150003 P4 Log Pow : < 0
TYLOSE MHS 150003 P4 Viscosity, kinematic : Not specifically applicable
TYLOSE MHS 150003 P4 Viscosity, dynamic : Not specifically applicable
TYLOSE MHS 150003 P4 Explosive properties : Product is not explosive. Dust may form explosive mixture in air.
TYLOSE MHS 150003 P4 Oxidising properties : No data available
TYLOSE MHS 150003 P4 Lower explosive limit (LEL) : 30 g/m³
TYLOSE MHS 150003 P4 Minimum ignition energy : > 10 mJ
TYLOSE MHS 150003 P4 Bulk density : 200 - 600 g/l
TYLOSE MHS 150003 P4 Conbustion class : 5
TYLOSE MHS 150003 P4 Smst explosion category : ST1
TYLOSE MHS 150003 P4 KSt : < 200 bar*m/s

Tylose MHS 150003 P4
Persistence and degradability Product is biodegradable. Does not affect the functioning of waste-water treatment plants.
In case of loss of large quantities, advice local authorities.
Chemical oxygen demand (COD) < 1500 mg/g
Tylose MHS 150003 P4
Log Pow < 0
Bioaccumulative potential Not potentially bioaccumulable

Tylose MHS 150003 P4 is a water-soluble, non-ionic, highly etherified, modified methyl hydroxyethyl cellulose powder. It provides very fast consistency development, high water demand, water retention, and heat stability, and moderate sag resistance and influence on cement hydration. This grade of methyl hydroxyethyl cellulose (MHEC) is ideal for use in block laying adhesives and gypsum mounting binders and spray plasters.
Recommended fields of application

 Plasters, gypsum based Thin layer plasters, gypsum based Gypsum-Lime-Plasters Tile adhesives

Application performance

Consistency development: very fast

Water retention: very high

Final consistency: moderate

Influence on cement hydration: moderate

Sag resistance: moderate

Heat stability: high

Water demand: high

Packaging, Storage, Safety instructions Packaging, Storage, Safety instructions Like all fine-particle organic substances, cellulose ethers constitute a dust explosion hazard. Dust formation and deposits must be kept to a minimum so that no ignitable dust/air mixtures can form. Ignition sources such as naked flames, hot surfaces, sparks and static electricity should be avoided. Tylose starts to decompose at about 200°C. Its ignition temperature is >360°C.

Tylose burns easily and the fire may spread. When stored in closed containers, or in its original packaging in a dry place. at room temperature, Tylose can be kept for a long time. In the case of high viscosity grades, a slow loss of viscosity can be measured after lengthy storage (>1 year). Tylose absorbs water from moist air. Once opened, container must be resealed and kept tightly closed. This Tylose-type is supplied in multi-ply paper bags with polyethylene intermediate layer and/or in big bags.