PRODUCTS

FERROUS GLUCONATE

CAS Number: 299-29-6
Formula: C12 H24 Fe O14
Molecular Weight :482.17
Boiling Point : 673.60 °C. @ 760.00 mm Hg
Flash Point : 707.00°F ( 375.20 °C )

Ferro gluconate is a type of iron. You normally get iron from the foods you eat.
In your body, iron becomes a part of your hemoglobin and myoglobin.
Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.
Ferro gluconate is used to treat or prevent iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).

Ferro gluconate may also be used for purposes not listed in this medication guide.
Ferro Gluconate is a form of mineral iron for oral administration.
Ferro Gluconate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa.
Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes.

Ferrous gluconate is yellow-gray or light yellow-green crystal particles or powder, with a slight caramel smell.
Soluble in water, 5% aqueous solution is acidic, almost insoluble in ethanol, the theoretical iron content is 12%.
Ferro gluconate is easy to absorb, has no irritation to the digestive system, no side effects, and has no effect on the sensory properties and flavor of the food.
Ferro gluconate can also be used as a drug to treat anemia.

Ferro gluconate can be used as a color-protecting agent and nutrient enhancer in food.
Ferro gluconate can be formed by neutralizing gluconate with reduced iron.
The characteristics of ferrous gluconate are high bioavailability, good solubility in water, mild flavor without astringency, and more fortification in milk drinks.
But Ferro gluconate is also easy to cause changes in food color and flavor, which limits its application to a certain extent.

Ferro Gluconate have Pale greenish-yellow to yellowish-grey powder or granules, which may have a faint odour of burnt sugar.
The color of ferrous gluconate/solution depends on pH; they are light yellow at pH 2, brown at pH 4.5, and green at pH 7.
The iron rapidly oxidizes at higher pH.
The melting point for D-gluconic acid, ferrous salt dihydrate (98%) is 188 °C, decomposes.

Ferrous gluconate is a salt of the gluconic acid which represents a compound of iron and two molecules of gluconic acid.
Ferrous gluconate is a yellow-green crystalline powder, with the characteristic odor similar to burnt sugar.
In the crystalline state ferrous gluconate is stable in the air, while its aqueous solution is sensitive to light.

The solubility of ferrous gluconate in water is 8.5 g in 100 cm3 of water at 20 °C.
Ferrous gluconate is poorly soluble in ethanol, and insoluble in ether.
Ferrous gluconate based preparations contain iron in the ferrous form, and their intake is recommended in the state of iron-deficiency anemia and bleeding.

The specific optical rotation is +6.7 deg at 25 °C (c=1, H2O).
Ferro gluconate is soluble with slight heating in water.
Ferro gluconate is practically insoluble in ethanol

Ferro gluconate is soluble in glycerin
1 gram ferro gluconate dissolves in about 10 ml of water with slight heating and in 1.3 ml of water at 100 °C.
Ferro gluconate forms supersaturated solutions which are stable for a period of time.

Molecular formula of Ferro Gluconate: C12H22FeO14•2H2O
Molecular weight of Ferro Gluconate:482
IUPAC Name of Ferro Gluconate: iron(2+);(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;dihydrate
Traits of Ferro Gluconate: yellow gray or light green fine powder or granules.
Quality indicators of Ferro Gluconate: Ferro Gluconate also meets the requirements of the Chinese, British and American Pharmacopoeias.
Uses of Ferro Gluconate: nutritional supplements, iron calcium fortifiers, pigment additives.

Content of Ferro Gluconate:
(dry basis)%: ≥95
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:8

Exact Mass:482.057020
Monoisotopic Mass:482.057020
Topological Polar Surface Area:285 Å²
Heavy Atom Count:29

Formal Charge:0
Complexity:165
Isotope Atom Count:0

Defined Atom Stereocenter Count:8
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0

Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes

Ferrous Gluconate is an iron mineral salt used in iron and multivitamin supplements.
“Ferrous” means “iron,” a mineral critical to the transportation of oxygen by red blood cells to the body's tissues.
Iron deficiency will result in a shortage of red blood cells (anemia), a potentially life-threatening condition.

Ferrous Gluconate is used in numerous iron supplements, so Ferrous Gluconate's price will vary.
However, a generic non-prescription iron supplement sold as Ferrous Gluconate will cost $7.57.
A Ferrous Gluconate coupon will reduce this price to $1.52 with a prescription.

Ferrous gluconate is a black dye.
Ferrous gluconate is composed of iron, bound to two molecules of gluconic acid, which is the acid form of glucose.
Ferrous gluconate is the black dye used to color ripe olives.
Ferrous gluconateis also used as am iron supplement to cure iron deficiency anemia.

Ferrous Gluconate can be used as a dietary ingredient and as a nutrient.
This product is known to be used for pharmaceutical applications.
Iron has a vital function in combining with protein and copper to make hemoglobin.
Iron also prevents fatigue and promotes good skin tone.

Why is it important for my child to take ferrous gluconate?
Anaemia is a blood condition where there is a lack of a protein called haemoglobin.
Haemoglobin is needed to carry oxygen in the blood and transport it around the body.
Children with anaemia are often pale, feel tired, have little energy, and may not grow or develop properly.

Ferrous gluconate is a form of iron that can be taken by mouth.
Ferrous gluconate helps the body to make more haemoglobin and so treat the anaemia.
Ferrous gluconate can also be used to prevent anaemia in children who are at risk of it or, for example, before surgery.

Iron(II) Gluconate (Ferrous Gluconate) is generally immediately available in most volumes.
High purity, submicron and nanopowder forms may be considered.
American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Ferrous Gluconate has a typical and custom packaging.

Ferrous Gluconate is a yellowish gray or pale greenish yellow powder or granules C12H22FeO14 used as a hematinic in the treatment of iron-deficiency anemia.
How should I store Ferrous Gluconate?
-Keep in a cool, dry place, away from direct sunlight
-Store at room temperature
-Keep the container tightly closed.
-Store in the original container.

Ferrous Gluconates are used for the treatment and prevention of iron deficiency.
Ferrous Gluconate is a form of iron.
Iron is necessary for the production of haemoglobin (protein in red blood cells), which carries oxygen around the body.
Iron is involved in the formation of myoglobin, a pigment that stores oxygen in muscles for use during exercise.

Ferrous Gluconate with food and drink
If you drink large amounts of tea, coffee or milk or milk products, or eat eggs and whole grain breads and cereals at the same time as taking Ferrous Gluconate, your body may absorb less of the iron contained in the tablets which can reduce the effects of ferrous gluconate.

Dietary supplement, food colour for ripe olives Iron(II) gluconate, or ferrous gluconate, is a black compound often used as an iron supplement.
Ferrous gluconateis the iron(II) salt of gluconic acid.
Ferrous gluconate is marketed under brand names such as Fergon, Ferralet, and Simron.
Ferrous gluconateis also present in the combination supplement dianazene, a vitamin mixture created by L. Ron Hubbard and used in the religion Scientology.

Water Solubility of Ferrous Gluconate:36.6 g/L
logP of Ferrous Gluconate:-2
logS of Ferrous Gluconate:-1.1

pKa of Ferrous Gluconate (Strongest Acidic):3.39
pKa of Ferrous Gluconate (Strongest Basic)   :-3
Physiological Charge of Ferrous Gluconate:-1

Hydrogen Acceptor Count of Ferrous Gluconate:7
Hydrogen Donor Count of Ferrous Gluconate:5
Polar Surface Area of Ferrous Gluconate:41.28 Å²
Rotatable Bond Count of Ferrous Gluconate:10

Refractivity of Ferrous Gluconate:49.11 m³·mol⁻¹
Polarizability of Ferrous Gluconate:16.5 Å³
Number of Rings:0
Bioavailability of Ferrous Gluconate:Yes

Rule of Five:Yes
Ghose Filter:No
Veber's Rule:No
MDDR-like Rule:No

Chemical Formula of Ferrous Gluconate:C12H22FeO14
IUPAC name of Ferrous Gluconate:λ²-iron(2+) ion bis(2,3,4,5,6pentahydroxyhexanoate)
Mass Composition of Ferrous Gluconate: C 32.31%; H 4.97%; Fe 12.52%; O 50.21%

Ferrous Gluconate delivers iron in each tablet.
Every cell in the human body contains iron, with the majority of the body's iron found in red blood cells that carry oxygen from the lungs to the rest of the body.
Preservative and gluten free.
No sugar, starch, artificial flavors, wheat, yeast or corn added.
Take ferrous gluconate on an empty stomach, at least 1 hour before or 2 hours after a meal.

Ferrous Gluconate is used in the treatment of:
-Pregnancy Complications, Hematologic
-Ferrous Gluconate is used in the prevention of:
-Anemia, Iron-Deficiency

Ferrous gluconate or iron (II) gluconate, with iron in the +2 oxidation state, can be used as an iron supplement in food, a color additive for ripe olives, also for the treatment of iron deficiency anemia in medical uses.
The European food additive number for Ferrous gluconate is E579.

How is Ferrous gluconate made?
Ferrous gluconate can be produced by the reaction of calcium gluconate, sulfuric acid, sodium carbonate and ferrous sulfate.

And the following are the brief manufacturing process:
Obtain a gluconic acid solution: sulfuric acid reacts with calcium gluconate.
Obtain ferrous carbonate: the reaction between sodium carbonate and ferrous sulfate.
Gluconic acid solution reacts with excess ferrous carbonate.
Ferrous gluconate can also be made from directly reacting gluconic acid (obtained from calcium gluconate) with iron powder.

The uses of ferrous gluconate in food including as a nutrient supplement, such as in vitamins and minerals supplement, also in infant formula.
Ferrous gluconate also can be used as a food coloring, making ripe olives black.

Pharmaceutical Uses Of Ferrous gluconate
Ferrous gluconate is used for treating or preventing iron deficiency anemia.
Besides ferrous gluconates pure form (powder or granular) sold as a bulk ingredient in the market, you can commonly find the tablet formulation of ferrous gluconate as an iron supplement with various dosages available in B2C market, for example, 324 mg, 325 mg, 300mg, 240 mg, 225 mg and so on.
Iron quantities in them are around 38mg, 38mg, 35mg, 26mg, 28mg, respectively. Iron quantities are calculated by [the quantity of ferrous gluconate] multiply [the molecular weight of iron]divide [the molecular weight of ferrous gluconate].
Ferrous gluconate can also be added in the production of multivitamin capsules and syrups.
Another two iron(II) salts, ferrous sulfate and ferrous fumarate can also be used to treat anemia.

Is Ferrous gluconate Safe to Eat?
Yes, it has been approved safe by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as the Joint FAO/WHO Expert Committee on Food Additives (JECFA).

FDA
Nutrient supplement: ferrous gluconate is generally recognized as safe (GRAS) when used as a nutrient supplement in food with no limitation other than current good manufacturing practice.
Also, Ferrous gluconate may be used in infant formula.
Color additive: Ferrous gluconate may be safely used for the coloring of ripe olives.
Feed additive: Ferrous gluconate is also GRAS when used as nutrients and/or dietary supplements in animal drugs, feeds, and related products.

Ferrous gluconate it vegan?
Yes, Ferrous gluconate is vegan as the raw material, calcium gluconate, sulfuric acid, sodium carbonate and ferrous sulfate are derived from the chemical synthesize, without the use of animal matter or products derived from animal origin.
So Ferrous gluconate is suitable for vegetarians.

Is Ferrous gluconate the same with ferric gluconate?
No, different with ferric gluconate, the iron in which present +3 oxidation state, Fe3+.

Is Ferrous gluconate gluten free?
Yes, it is gluten free as it does not contain wheat, rye, barley, or crossbreeds of these grains, therefore can be used for people with celiac disease.

Synonyms:
-biofergate
-ferrin 55
-ferroglyconicum
-gluconic acid iron salt
-iron (II) di-D-gluconate
-iron digluconate
-iron gluconate
-iron, bis(D-gluconato-O1,O2)-
-iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
-iron(II) di-D-gluconate
-sodium ferric gluconate complex
-ferrous gluconate
-ferroglyconicum
-glucoferron