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Glyceryl Triacetate = Triasetin (Triacetin)
Glyceryl Triacetate, is the organic compound with the formula C3H5(OCOCH3)3.
Glyceryl Triacetate is classified as a triglyceride, i.e., the triester of glycerol.
Glyceryl Triacetate is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point.
It has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations.
Glyceryl Triacetate is one of the glycerine acetate compounds.
Triacetin is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.
Glyceryl Triacetate has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.
It has a role as a plant metabolite, a solvent, a fuel additive, an adjuvant, a food additive carrier, a food emulsifier, a food humectant and an antifungal drug.
It derives from an acetic acid.
The triglyceride 1, 2, 3-triacetoxypropane is more generally known as triacetin and glycerin triacetate.
Glyceryl Triacetate the triester of glycerol and acetylating agents, such as acetic acid and acetic anhydride.
Glyceryl Triacetate is a colorless, viscous and odorless liquid with a high boiling point.
Triacetin (Glyceryl Triacetate) is used as an ingredient in many food and cosmetic products.
Its high solvency power and low volatility make triacetin a good solvent and fixative for many flavors and fragrances.
One of its main uses is as a plasticizer in chewing gum.
The United States Food and Drug Administration affirmed triacetin as generally recognized as safe (GRAS) for use in human food.
Glyceryl Triacetate is also generally recognized as safe in animal feeds, as a pesticide adjuvant, and in food packaging.
Glyceryl Triacetate (triacetin) is an aromatic chemical compound widely used as a food additive. For example, it is used as a solvent and humectant in sweeteners.
It is also used as a humectant, plasticizer and solvent auxiliaries in pharmaceutical products.
Triacetin (triacetin) (glyceryl triacetate) is used as an ingredient in many food and cosmetic products.
Glyceryl Triacetate high solubility and low volatility make triacetin a good solvent and stabilizer for many flavors and odours.
One of its main uses is in chewing gums as a plasticizer.
The United States Food and Drug Administration has confirmed that triacetin is generally considered safe (GRAS) for use in human foods.
They are also considered safe for use in animal feeds, as pesticides, and in food packaging.
Glyceryl Triacetate (triacetin) can also be used as an anti-knock agent in gasoline, reducing engine knock and improving the cold and viscosity properties of biodiesel.
Spectrum Chemical manufactures and distributes fine chemicals with quality you can count on including those with CAS number 102-76-1, Whether you call it Triacetin, Glycerol Triacetate or 1 -2 -3-Propanetriol Triacetate you can be assured the Triacetin products offered by Spectrum, meet or exceed the grade requirements or specifications for each individual product.
Uses: Triacetin is a common food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Glyceryl Triacetate is used as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.
Potential uses: The plasticizing capabilities of triacetin have been utilized in the synthesis of a biodegradable phospholipid gel system for the dissemination of the cancer drug paclitaxel (PTX).
In the study, triacetin was combined with PTX, ethanol, a phospholipid and a medium chain triglyceride to form a gel-drug complex.
This complex was then injected directly into the cancer cells of glioma-bearing mice.
The gel slowly degraded and facilitated sustained release of PTX into the targeted glioma cells.
Triacetin can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
It has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
Glyceryl Triacetate is believed to be safe to get over half of one's dietary energy from triacetin.
Triacetin(Glycerol triacetate) also known as glyceryl triacetate, is pharmaceutical excipient used in manufacturing of capsules and tablets, and has been used as a humectant, plasticizer, and solvent. It is a liquid, and has been approved by the FDA as a food additive. Triacetin is a water-soluble short-chain triglyceride that may also have a role as a parenteral nutrient according to animal studies.
Glyceryl Triacetate is also used in the perfume and cosmetic industries.
Synthesis: Glyceryl Triacetate was first prepared in 1854 by the French chemist Marcellin Berthelot.
Triacetin was prepared in the 19th century from glycerol and acetic acid.
Its synthesis from acetic anhydride and glycerol is simple and inexpensive.
3 (CH3CO)2O + 1 C3H5(OH)3 → 1 C3H5(OCOCH3)3 + 3 CH3CO2H
This synthesis has been conducted with catalytic sodium hydroxide and microwave irradiation to give a 99% yield of triacetin.
It has also been conducted with a cobalt(II) Salen complex catalyst supported by silicon dioxide and heated to 50 °C for 55 minutes to give a 99% yield of triacetin.
Safety:The US Food and Drug Administration has approved it as Generally Recognized as Safe (GRAS) food additive and included it in the database according to the opinion from the Select Committee On GRAS Substances (SCOGS).
"Triacetin and two types of acetooleins have been found to be without toxic effects in long-term feeding tests in rats at levels that were several orders of magnitude greater than those to which consumers are exposed.
Three types of acetostearins have been found to be without toxic effects in long-term feeding tests in rats at levels up to 5 g per kg per day.
This contrasts with an estimated human consumption of a fraction of a milligram per kg per day.
It is recognized that at an even higher feeding level (10 g per kg per day) male rats developed testicular atrophy and female rats, uterine discoloration.
However, such a level which would amount to 50 g or more for an infant and 600 g for an adult per day, is vastly higher than would be possible in the consumption of foods to which acetostearins are added for functional purposes."
Triacetin is included in the SCOGS database since 1975. Triacetin was not toxic to animals in studies of exposure through repeated inhalation over a relatively short period.
Uses:
It is an artificial chemical compound, commonly used as a food additive, for instance as a solvent in flavourings, and for its humectant function, with E number E1518 and Australian approval code A1518.
Triacetin is also a component of casting liquor with TG and as an excipient in pharmaceutical products, where it is used as a humectant, a plasticizer, and as a solvent.
Triacetin can also be used as a fuel additive as an antiknock agent which can reduce engine knocking in gasoline, and to improve cold and viscosity properties of biodiesel.
In a 1994 report released by five top cigarette companies, triacetin was listed as one of the 599 cigarette additives.
The triacetin is applied to the filter as a plasticizer.
It has been considered as a possible source of food energy in artificial food regeneration systems on long space missions.
Glyceryl Triacetate is believed to be safe to get over half of one’s dietary energy from triacetin.
Synonyms:
Triacetin
Glyceryl triacetate
102-76-1
Glycerol triacetate
Glycerin triacetate
Enzactin
Triacetine
Triacetylglycerol
Fungacetin
Glyped
Triacetyl glycerine
Vanay
Kesscoflex TRA
Features:
Formula: C9H14O6
Boiling point: 258 °C
Molar mass: 218.21 g/mol
Melting point: 3 °C
CAS No: 102-76-1
Molar mass: 218.21 g mol−1
Appearance: Colorless oily liquid
Density: 1.155 g/cm3[3]
Melting point: −78 °C (−108 °F; 195 K) at 760 mmHg
Boiling point: 259 °C (498 °F; 532 K) at 760 mmHg
pH value: 5.0 – 6.0 (50 g/l, H₂O, 20 °C)
Vapor pressure: <0.1 hPa (20 °C)
Resolution: 64 g/l
Viscosity: 23 cP (20 °C)
Storage and Transport Information: +15°C to +25°C
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Density: 1.155 g/mL
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Melting Point: 2°C to 4°C |
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Boiling Point: 257°C to 259°C |
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Flash Point: 149°C (300°F) |
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Assay Percent Range: 99% |
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Quantity: 500g |
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Solubility Information: Slightly miscible with water,carbon tetrachloride and carbondisulfide. Miscible with acetone,ethanol,benzene and chloroform. |
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Formula Weight: 218.21 |
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Percent Purity: 99% |
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Chemical Name or Material: Glycerol triacetate |
Colorless, odorless oily liquid.
Miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil.
It is slightly soluble in water. 5.9 g / 100 ml water solubility 25 °C.
MeSH Entry Terms:
Enzactin
Triacetin
Triacetyl glycerol
Triacetyl-glycerol
Triacetylglycerol
Usage areas:
As a plasticizer and odor stabilizer, ink solvent, also in drug and dye synthesis,
As chromatographic fixative, solvent, hardener and odor stabilizer,
Humidifiers; carrier solvents; as plasticizer, (can absorb carbon dioxide from natural gas.)
In the manufacture of cosmetics, pharmaceuticals and paints, as a plasticizer for cigarette filter rods,
In cosmetics, casting, medicine, paint and other industries,
Used as substrate for lipase, perfume fixative, solvent, gas chromatographic fixative (85℃, solvent: methanol, chloroform maximum temperature), gas and aldehyde analysis separation.
Industry Uses:
Adhesives and sealant chemicals
Agricultural chemicals (non-insecticide)
finishing agents
Intermediates
Oxidizing / reducing agents
Paint additives and coating additives not described by other categories
Plasticizers
Processing aids not otherwise listed
Solvents (becomes part of product formulation or mix)
Build
Casting
refractive coating
Consumer Uses:
Adhesives and sealants
Agricultural products (non-pesticidal)
Construction / building materials (not covered in another group)
Cleaning and care products
Fabric, textile and leather products (not covered in another group)
Food and drink
Food ingredients
food packaging
Lawn and garden care products
Metal products (not covered in another group)
Non-TSCA use
Paints and coatings
paper products
Photographic materials, film and photographic chemicals
Plastic and rubber products not found elsewhere
Plasticizer
water treatment products
