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CAS: 124-68-5
MF: C4H11NO
MW: 89.14
EINECS: 204-709-8
General Description
Aminoisobutanol a clear light colored liquid.
Insoluble in water and about the same density as water.
Flash point 172°F.
Aminoisobutanol used to make other chemicals.
Aminoisobutanol is colorless liquid that is classified as an alkanolamine.
Aminoisobutanol is a useful buffer and a precursor to numerous other organic compounds.
Reactivity Profile
Aminoisobutanol is an aminoalcohol.
Amines are chemical bases.
They neutralize acids to form salts plus water.
These acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Aminoisobutanol may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides 2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations.
Aminoisobutanol has phototoxic effect as it can interact and penetrate above the sebum layer.
However, Aminoisobutanol is not carcinogenic.
Uses
Aminoisobutanol is used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.
Aminoisobutanol is also used in ATR-FTIR spectroscopic investigation of the carbon monoxide absorption characteristics of a series of heterocyclic diamines.
Aminoisobutanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells.
Aminoisobutanol is used for the preparation of buffer solutions.
Aminoisobutanol is a component of the drugs ambuphylline and pamabrom.
Aminoisobutanol is also used in cosmetics.
Aminoisobutanol is a precursor to oxazolines via its reaction with acyl chlorides.
Via sulfation of the alcohol, the compound is also a precursor to 2,2-dimethylaziridine.
Aminoisobutanol is used in the synthesis of Fepradinol & G-130.
Aminoisobutanol is also used for Isobucaine, and Radafaxine.
Aminoisobutanol Chemical Properties
Melting point: 24-28 °C (lit.)
Boiling point: 165 °C (lit.)
Density: 0.934 g/mL at 25 °C (lit.)
Vapor density: 3 (vs air)
Vapor pressure: <1 mm Hg ( 25 °C)
Refractive index: n20/D 1.4455(lit.)
Fp: 153 °F
Storage temp.: Store below +30°C.
Solubility H2O: 0.1 M at 20 °C, clear, colorless
Form: Low Melting Solid
Color: Colorless
Specific Gravity: 0.934
PH: 11.0-12.0 (25℃, 0.1M in H2O)
PH Range: 9.0 - 10.5
pka: 9.7(at 25℃)
Water Solubility: miscible
λmax λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck: 14,449
BRN: 505979
Stability: Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.
InChIKey: CBTVGIZVANVGBH-UHFFFAOYSA-N
LogP: -0.63 at 20℃
CAS DataBase Reference: 124-68-5(CAS DataBase Reference)
NIST Chemistry Reference: Aminoisobutanol-(124-68-5)
EPA Substance Registry System: Aminoisobutanol (124-68-5)
Synthesis
The synthesis of Aminoisobutanol is as follows:
In a 1L three-neck flask with mechanical stirring, first add 200ml of water, add a few drops of dilute sulfuric acid to make Aminoisobutanol slightly acidic (pH=3.5-4), then heat to 40-50, and start adding 99.0 at the same time.
2,2-Dimethylaziridine and 400ml dilute sulfuric acid aqueous solution, keep the temperature and slightly acidic condition, drop 2,2-dimethylaziridine, then continue to react at this temperature 1h, then under reduced pressure distillation to remove 80% of the water, add 500ml ethanol to the obtained system, neutralize with 30% sodium hydroxide to pH=9.5-10, filter and remove the salt, the obtained filtrate is distilled out of ethanol under normal pressure , And then distilled under reduced pressure to obtain crude 2-amino-2-methyl-1-propanol.
This crude product is then rectified to obtain 112.9g Aminoisobutanoll refined product with a yield of about 91.0%, chromatographic purity is about 99.4%.
Synonyms
2-Amino-2-methyl-1-propanol
124-68-5
2-Amino-2-methylpropan-1-ol
Aminomethylpropanol
1-Propanol, 2-amino-2-methyl-
2-Aminoisobutanol
Isobutanol-2-amine
AMP Regular
2-AMINO-2-METHYLPROPANOL
Aminomethyl propanol
2-Methyl-2-aminopropanol
2-Aminodimethylethanol
2-Amino-2-methyl-propan-1-ol
Hydroxy-tert-butylamine
Corrguard 75
2-Amino-2,2-dimethylethanol
AMP (thinner)
Amp-95
Isobutanolamine
1,1-Dimethyl-2-hydroxyethylamine
2-Methyl-2-aminopropanol-1
2-Hydroxymethyl-2-propylamine
AMP 95
2-Amino-1-hydroxy-2-methylpropane
.beta.-Aminoisobutanol
AMP 75
NSC 441
KV 5088
MFCD00008051
NSC-441
LU49E6626Q
DSSTox_CID_7032
DSSTox_RID_78283
DSSTox_GSID_27032
beta-Aminoisobutanol
Caswell No. 037
CAS-124-68-5
HSDB 5606
EINECS 204-709-8
EPA Pesticide Chemical Code 005801
BRN 0505979
UNII-LU49E6626Q
2-Methyl-2-amino-1-propanol
AI3-03947
2-Amino-2-methyl-1-propanol, 95%
A-Aminoisobutyl alcohol
2,2-Dimethyl-ethanolamine
Amino-2,2-dimethylethanol
2-amino 2-methyl propanol
2-amino-2-methyl propanol
2-Amino-2-methyl-1-propanol (90% or less)
EC 204-709-8
Hydroxymethyl-2-propylamine
2-Amino-2-methyl-propanol
Amino-2-methyl-1-propanol
H2NC(CH3)2CH2OH
NCIOpen2_009031
2-amino-2-methyl-1propanol
2-amino-2-methylpropan-1ol
2amino-2-methyl-1-propanol
Oprea1_147215
2-amino-2-methylpropan-l-ol
2-amino-2-methyl 1-propanol
2-amino-2-methyl-1 propanol
2-methyl-2-aminopropan-1-ol
1-Propanol-2-amino-2-methyl
AMP, Technical Grade, 95%
2-amino-2,2,dimethyl-ethanol
CHEMBL122588
NSC441
2-amino-2 -methyl-1-propanol
2-amino-2- methylpropan-1-ol
2-amino-2-methyl-1 -propanol
AMINOMETHYLPROPANOL [II]
DTXSID8027032
2-Amino-2-methyl-propane-1-ol
2-hydroxy-1,1-dimethylethylamine
1-hydroxy-2-methyl-2-propylamine
3-hydroxy-2-methyl-2-propylamine
1-hydroxy-2-methyl-2-aminopropane
AMINOMETHYL PROPANOL [INCI]
AMY25550
STR01693
ZINC1555527
Tox21_201780
Tox21_303149
2-Amino-2-methylpropanol (~95%)
BBL023024
STL284638
1-PROPANOL,2-AMINO,2-METHYL
AKOS000119511
WLN: ZX1 & 1 & 1Q
CS-W013743
SB83772
2-AMINO-2-METHYLPROPANOL [HSDB]
NCGC00249118-01
NCGC00257048-01
NCGC00259329-01
2-Amino-2-methyl-1-propanol, 93-97%
2-AMINO-2-METHYL-1-PROPANOL [MI]
DB-041780
A0333
FT-0611018
FT-0661937
2-AMINO-2-METHYL-1-PROPANOL [VANDF]
2-AMINO-2-METHYL-1-PROPANOL [WHO-DD]
P20005
Q32703
2-Amino-2-methyl-1-propanol, BioXtra, >=95%
A805277
Q-200228
2-Amino-2-methyl-1-propanol, Technical Grade, 95%
2-Amino-2-methyl-1-propanol, purum, >=97.0% (GC)
2-Amino-2-methyl-1-propanol, technical, >=90% (GC)
F2190-0372
2-Amino-2-methyl-1-propanol, BioUltra, >=99.0% (GC)
2-Amino-2-methyl-1-propanol, SAJ first grade, >=98.0%
2-Amino-2-methyl-1-propanol, ~5% Water, technical grade, 90%
