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Molecular Formula: C6H8Na2O4
Molecular Weight: 190.10
CAS Number: 7486-38-6
European Community (EC) Number: 231-293-5
MDL Number: MFCD00070498
E356 (Sodium adipate) has been incorporated into controlled-release formulation matrix tablets to obtain a pH-independent release for both weakly basic and weakly acidic drugs.
E356 (Sodium adipate) has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of hydrophilic drugs.
The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when E356 (Sodium adipate) was used as a pore-forming agent without affecting release in the acidic media.
E356 (Sodium adipate) is used to make bisobrin an antifibrinolytic.
E356 (Sodium adipate) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
E356 (Sodium adipate) is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Acidity Regulator / Buffering Agent - Changes or maintains the acidity or basicity of food/cosmetics.
Flavor / Flavoring / Flavor Enhancer - Provides or enhances a particular taste or smell.
E356 (Sodium adipate) occurs naturally in living cells, but is commercially prepared from the oxidation of cyclohexanol by concentrated nitric acid.
Small but significant amounts of E356 (Sodium adipate) are used as a food ingredient (E355) as a flavorant and gelling aid.
E356 (Sodium adipate) is used in some calcium carbonate antacids to make them tart.
As an acidulant in baking powders, Hexanedioic acid, disodium salt avoids the undesirable hygroscopic properties of tartaric acid.
Hexanedioic acid, disodium salt, rare in nature, does occur naturally in beets, but this is not an economical source for commerce compared to industrial synthesis.
E356 (Sodium adipate) is approved to use as food additive in EU and generally recognized as safe food substance in US.
Hexanedioic acid, disodium salt is the sodium salt of E356 (Sodium adipate).
The function(s) performed by the food additive when used in cooking.
White odourless crystals or crystalline powder
E356 (Sodium adipate) is a sodium salt of and adipic (hexanedioic) acid - a C6 dicarboxylic acid.
Hexanedioic acid, disodium salt is a colorless crystalline solid which is readily soluble in water and is effective as an acidity regulator and complexing agent.
The acidity regulatory property of E356 (Sodium adipate) finds many uses in pharmaceutical drug development.
In addition, E356 (Sodium adipate) is used as a stabilizer of PVC.
Sodium salt of E356 (Sodium adipate).
E356 (Sodium adipate) is a synthetic food acid from nitric acid or from beetroot.
As Hexanedioic acid, disodium salt is synthetic using highly toxic petroleum hexanes, E356 (Sodium adipate) would not be sensible to use this product on any long term basis.
Sodium Adipic is used as an acidity regulator.
Only a small amount can be metabolised by humans and is listed as having teratogenic properties, which is an abnormal congenital deformity in embryos.
Adipate is the salt product of a reaction between E356 (Sodium adipate) and a basic, or high pH, compound.
A salt, in the chemical sense rather than the table salt meaning, is an ionic compound with no net charge that is formed when an acid reacts with a base.
An ionic compound occurs when a positively charged ion bonds with a negatively charged ion.
There are several forms of adipate with different compositions and uses.
Examples include the plastic additives Bis(2-ethylhexyl) adipate (DEHA) and dioctyl adipate (DOA), and the food additives potassium adipate and E356 (Sodium adipate).
E356 (Sodium adipate), from which adipate arises, takes the form of a white powder that is typically manufactured rather than found in nature.
Chemically, E356 (Sodium adipate) belongs to the class of dicarboxylic acids, organic compounds that have two carboxylic acid functional groups.
A compound is organic if it contains carbon.
The chemical formula of E356 (Sodium adipate) is (CH2)4(CO2H)2.
As an E356 (Sodium adipate), when it is added to water, E356 (Sodium adipate) releases hydrogen ions, or charged hydrogen atoms, into the solution, giving it a lower pH and a sour taste.
In E356 (Sodium adipate)s capacity as a food additive, adipate serves as an acidity regulator, or a pH control agent.
An acidity regulator is added to alter the acidity or basicity of a food.
Each acidity regulator has an E number listing.
Potassium adipate, which is the potassium salt formed from an E356 (Sodium adipate) reaction, has the E number “E357” and E356 (Sodium adipate), which is the sodium salt arising from an E356 (Sodium adipate) reaction with a base, has the E number “E356.”
These compounds lend a sour flavor to foods and may be used as a gelling agent.
E356 (Sodium adipate) may be prepared by reaction of E356 (Sodium adipate) with sodium carbonate.
Also, the neutralization of sodium hydroxide with an ethanolic solution of E356 (Sodium adipate) adipic supplies.
Property Name and Property Value
Molecular Weight: 190.10
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 3
Exact Mass: 190.02179730
Monoisotopic Mass: 190.02179730
Topological Polar Surface Area: 80.3 Ų
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 103
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 338.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000018 mmHg @ 25.00 °C. (est)
Flash Point: 343.00 °F. TCC ( 172.70 °C. ) (est)
logP (o/w): 0.079 (est)
Color: White
Quantity: 25g
Formula Weight: 190.11
Physical Form: Crystal-Powder at 20°C
Percent Purity: ≥98.0% (GC,T)
Chemical Name or Material: DiE356 (Sodium adipate)
Density: 1.25g/cm3
Purity
Water content: Not more than 3 % (Karl Fischer)
Arsenic: Not more than 3 mg/kg
Lead: Not more than 2 mg/kg
Mercury: Not more than 1 mg/kg
Use and Manufacturing
Use Classification
-Food additives
Industry Uses
-Lubricants and lubricant additives
-Processing aids, not otherwise listed
General Manufacturing Information:
Industry Processing Sectors
-Paper manufacturing
-Petroleum lubricating oil and grease manufacturing
-E356 (Sodium adipate) is used in the following products: lubricants and greases, non-metal-surface treatment products, polymers, adhesives and sealants, coating products, fillers, putties, plasters, modelling clay and cosmetics and personal care products.
-Hexanedioic acid, disodium salt is used in the following areas: formulation of mixtures and/or re-packaging.
-E356 (Sodium adipate) is used for the manufacture of: rubber products, plastic products and mineral products (e.g. plasters, cement).
-Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and of substances in closed systems with minimal release.
Manufacture
Release to the environment of this substance can occur from industrial use: manufacturing of the substance.
How to use it safely
ECHA has no data from registration dossiers on the precautionary measures for using this substance.
Guidance on the safe use of the substance provided by manufacturers and importers of this substance.
Consumer Uses
Hexanedioic acid, disodium salt is used in the following products: adhesives and sealants, coating products, fillers, putties, plasters, modelling clay, non-metal-surface treatment products, lubricants and greases, polymers and cosmetics and personal care products.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Article service life
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
DiE356 (Sodium adipate) is used in the following products: non-metal-surface treatment products, lubricants and greases, polymers, adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.
E356 (Sodium adipate) is used in the following areas: formulation of mixtures and/or re-packaging.
E356 (Sodium adipate) is used for the manufacture of: rubber products, plastic products and mineral products (e.g. plasters, cement).
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).
Formulation or re-packing
DiE356 (Sodium adipate) is used in the following products: adhesives and sealants, fillers, putties, plasters, modelling clay, lubricants and greases, coating products, finger paints, non-metal-surface treatment products, polymers and cosmetics and personal care products.
Release to the environment of this substance can occur from industrial use: formulation in materials and formulation of mixtures.
Sodium Adipic is found in Herbal salts.
DiE356 (Sodium adipate) is metabolised in the body or excreted in the urine.
E356 (Sodium adipate) is used as a firming and raising agent used in baking powder, beer, all fruit drinks, jams, pudding mixes, ice blocks, margarine, etc.
Also used in the production of plastics including PVC, and also in antacids, which is strange considering diE356 (Sodium adipate) is an acid.
E356 (Sodium adipate) is used as a food additive as a complexing agent and an acidity regulator.
In addition, it is used as a stabilizer of PVC.
Features
E356 (Sodium adipate) is a colorless solid which is readily soluble in water.
Hexanedioic acid, disodium salt crystallizes as the hemihydrate in shiny, slightly hygroscopic flakes.
The enthalpy of solution of E356 (Sodium adipate) at 298.15 K is 15.70 kJ · mol -1.
In the electrolysis of an aqueous solution of E356 (Sodium adipate) produced cyclobutane.
Non-graphited, water-based die lubricant formulated to provide effective lubrication and release when hot forging on presses, upsetters and hammers
Hexanedioic acid, disodium salt is capable of wetting dies at temperatures as high as 700 deg F, and provides good metal flow
Good film formation at high temperatures
Contains water-soluble, organic salts for lubrication
Stable in concentrate and diluted form
Excellent for hot forging
Effective release and lubrication at high die temperatures
Elimination of graphite overspray leads to a cleaner plant environment
Less plugging of spray nozzles
Not damaged by freezing
EPA TSCA Commercial Activity Status
Hexanedioic acid, sodium salt (1:2): ACTIVE
Experimental Properties
Physical Description
-Liquid
-White odourless crystals or crystalline powder.
Melting Point: 151-152 °C (for E356 (Sodium adipate))
Solubility: Approximately 50 g/100 ml water (20 °C)
DETAILS
Substance Class: Chemical
Record UNII: 3XG6T5KYKM
Record Status: Validated (UNII)
Stability and Reactivity Data
Stability: It is stable.
Conditions of instability: Incompatible materials.
Incompatibility with various substances: Heat, light, strong oxidizing agents.
Polymerization: Will not occur.
InChI Key: KYKFCSHPTAVNJD-UHFFFAOYSA-L
Canonical SMILES: C(CCC(=O)[O-])CC(=O)[O-].[Na+].[Na+]
Molecular Formula: C6H8Na2O4
Identifiers
Related CAS: 124-04-9
UNII: 3XG6T5KYKM
DSSTox Substance ID: DTXSID1044726
E number: E356
Reaxys Registry Number: 4029370
Synonyms
E356 (Sodium adipate)
DiE356 (Sodium adipate)
7486-38-6
E356 (Sodium adipate) Disodium Salt
Hexanedioic acid, disodium salt
disodium;hexanedioate
UNII-3XG6T5KYKM
3XG6T5KYKM
disodium hexanedioate
Hexanedioic acid, sodium salt
E356 (Sodium adipate), sodium salt
E356 (Sodium adipate), DISODIUM SALT
EINECS 231-293-5
Hexanedioic acid, sodium salt (1:?)
Hexanedioic acid, sodium salt (1:2)
1,4-Butanedicarboxylic acid disodium salt
EINECS 245-577-1
ACMC-209ow9
EC 231-293-5
SCHEMBL107905
DTXSID1044726
AMY38501
MFCD00070498
AKOS025295713
AS-75598
A0592
FT-0719498
D88288
Q423296
E356 (Sodium adipate)
