PRODUCTS

NEOTAME

Neotame is a non-caloric artificial sweetener.
By mass, Neotame is 8000 times sweeter than sucrose.
Neotame has no notable off-flavors when compared to sucrose.
Neotame enhances original food flavors.
Neotame can be used alone, but is often mixed with other sweeteners to increase their individual sweetness (i.e. synergistic effect) and decrease their off-flavors (e.g. saccharin).
Neotame is chemically somewhat more stable than aspartame.
Neotame's use can be cost effective in comparison to other sweeteners as smaller amounts of neotame are needed.
Neotame is suitable for use in carbonated soft drinks, yogurts, cakes, drink powders, bubble gums among other foods. It can be used as a table top sweetener for hot drinks like coffee.
Neotame covers bitter tastes (e.g. caffeine).

In 2002, FDA approvedNeotame as a non-nutritive sweetener and flavor enhancer within United States in foods generally, except meat and poultry.
In 2010, Neotame was approved for use in foods within EU with the E number E961.
Neotame has also been approved as an additive in many other countries outside US and EU.

Neotame's metabolism is fast and is not retained in the body.
Methanol forms in its metabolism.
Only trace amounts of neotame are added to foods, so the amount of methanol is insignificant for health.
Neotame is safe for type 2 diabetics and those with phenylketonuria.

A new sweetener derived from aspartame is thousands of times sweeter than sugar and does not have the undesirable taste characteristics common to some high-intensity sweeteners.
Neotame is a dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
Neotame has a role as an environmental contaminant, a xenobiotic and a sweetening agent

Neotame is a no-calorie sweetener, which is a derivative of the dipeptide composed of the amino acids, aspartic acid and phenylalanine.
The components of neotame are joined together to form a uniquely sweet ingredient.

Relative Sweetness: Neotame is sweeter than other marketed no-calorie sweeteners and is approximately 30-40 times sweeter than aspartame; 7,000-13,000 times sweeter than sugar.
Neotame will deliver comparable sweetness to sucrose in various applications.

Metabolism: Quickly metabolized and fully eliminated by the body via normal biological processes.

Assets: Neotame has a clean, sweet taste like sucrose and unique flavor enhancement properties.
At projected trace levels of use, neotame will provide a full, sweet taste in foods and beverages.

Applications of Neotame
Has applicability in foods and beverages, including but not limited to, chewing gum, carbonated soft drinks, refrigerated and non-refrigerated ready-to-drink beverages, tabletop sweeteners, frozen desserts and novelties, puddings and fillings, yogurt-type products, baked goods and candies.
Neotame can also be used in both cooking and baking applications.

Product Description of Neotame
Application
New sweetener is a new sweetener with pure sweetness.
Neotame has no bitterness and metal taste that other sweeteners often bring.
Neotame's sweetness is 7000-13000 times that of sucrose and 30-60 times that of aspartame.
Neotame is used as a new food additive in all kinds of foods. Neotame can be combined effectively with other sweeteners.
When formulated with sugar, sucralose and aspartame, Neotame is able to deliver the right sweetness onset while masking bitter taste attributes.
In particular, Neotame excels in enhancing flavors, such as berry and citrus fruits.

Neotame is a derivative of a dipeptide compound of the amino acids - aspartic acid and phenylalanine.
Neotame has been developed as a sweetener with a high degree of sweetness and is obtained by N-alkylating aspartame.
Neotame's degree of sweetness varies according to the kind of food and blend composition.
Neotame is 7000 to 13,000 times and about 30 to 60 times sweeter than sugar and aspartame respectively.
Neotame is rapidly metabolized, completely eliminated and does not accumulate in the body.
The major metabolic pathway of neotame is hydrolysis of the methyl ester by esterase which is present throughout the body.
This yields de-esterified neotame, the major metabolite and a significant amount of methanol.
Due to the presence of the 3-3-di-methylbutyl group, peptidases which would typically break the peptide bond between the aspartic acid and phenylalanine moieties are essentially blocked, thus reducing the availability of phenylalanine.
Neotame was approved by the USFDA as a general purpose sweetener in July 2002.

Identifiers of Neotame
CAS Number: 165450-17-9
CHEBI:83503
ChemSpider: 7986751
ECHA InfoCard: 100.109.344
E number: E961 (glazing agents, ...)
PubChem CID: 9810996
UNII: VJ597D52EX

Uses of Neotame
Since Neotame is 6,000 sweet than sugar, only a very low amount is needed to sweeten the low/reduced-calorie food and drink.
Meanwhile, Neotame has better heat stability over aspartame, and thus can be used in cooking and baking products where aspartame cannot.
Neotame is also used to strengthen the sweetness in the blends with other high-intensity sweeteners.

The following food list may contain neotame:
Chewing gum
Carbonated soft drinks
Tabletop sweeteners
Frozen desserts, yogurt
Baked goods
Preserved fruits
Salad dressings
Bakery
The property of heat-tolerant makes it ideal for baking applications, such as in cookies, cakes and muffins.

Beverages
Stable in carbonated drinks and can be used in powdered drinks and juices to lower the sugar content and reduce the calorie intake while maintaining the sweet taste.

Table top sweeteners
Without hygroscopicity makes it suitable as a sweetener in table-top sweeteners.

Confectionery
This ingredient can be used together with sugar alcohols in confectionery products, such as chocolates, gums, and candies.

Safety of Neotame
In US and EU, the acceptable daily intake (ADI) of neotame for humans is 0.3 and 2 mg per kg of bodyweight (mg/kg bw), respectively.
NOAEL for humans is 200 mg/kg bw per day within EU.
Estimated possible daily intakes from foods are well below ADI-levels. Ingested neotame can form phenylalanine, but in normal use of neotame, this is not significant to those with phenylketonuria.
Neotame also has no adverse effects in type 2 diabetics.
Neotame is not considered to be carcinogenic or mutagenic.

Sweetness
Neotame is sweet because it binds to TAS1R2-receptors of mouth as an agonist.
Aspartame binds to the same receptor.

Water solutions of neotame, that are equivalent in sweetness to sucrose water solutions, increase logarithmically in relative sweetness as the sucrose concentration of a comparably sweet sucrose solution increases, until a plateau is reached.
Maximum sweetness is reached at neotame solution concentrations that are relatively as sweet as a water solution that is 15.1 percentage sucrose by weight, i.e. at 15.1 sucrose equivalence % (SE%).
For comparison, acesulfame K, cyclamate and saccharin reach their maximum sweetness at 11.6 SE%, 11.3 SE% and 9 SE%, respectively.

Neotame is a high-potency sweetener, and it is 6,000 to 10,000 times sweeter than sugar (sucrose), and even around 30 to 60 times sweeter than aspartame.
Neotame contains flavor-enhancing properties and compared to sucrose or aspartame Neotame has a relatively lower cost per sweetness factor.

Chemistry of Neotame
Structure
Neotame is formally a secondary amine of 3,3-dimethylbutanal and aspartame.
The latter is a dipeptide of phenylalanine and aspartic acid.
Neotame has 2 stereocenters and 4 stereoisomers.
Sweetness is due to the (2S),(3S)-stereoisomer.

Spectroscopy of Neotame
Neotame NMR spectroscopy identifies its structure with a peak at 0.84 ppm indicating the three methyl groups on the carbon chain bonded to the nitrogen.

Synthesis of Neotame
Neotame is synthesized from aspartame through a reductive alkylation with 3,3-dimethyl-butylaldehyde in a palladium catalyst with methanol.
The stereochemistry of aspartame is conserved during the synthesis and therefore, neotame and aspartame have the same stereochemistry.
(2S),(3S)-stereoisomer of aspartame is needed to synthesize the (2S),(3S)-stereoisomer of neotame.

Properties and reactivity of Neotame
Neotame has similar stability as aspartame, but has greater stability especially in heated and dairy foods.
Increased temperature, moisture or pH increase losses, and are the main relevant properties of a food when considering the stability of neotame.
For example, about 90% of original neotame remains after 8 weeks of storage in pH 3.2 beverages.
Neotame is especially stable as a dry powder at room temperature and humidity even if mixed with e.g. glucose or maltodextrin, and is relatively inert in foods with reducing sugars like fructose.

Unlike aspartame, neotame doesn't form diketopiperazines via intra-molecular cyclization due to its N-alkyl substitution with 3,3-dimethylbutyl.
This increases its heat stability.

Over 1000 g of neotame dissolves in 1 kg of ethanol at 15 °C.
At 15 °C the solubility of neotame is 10.6 g/kg in water and 43.6 g/kg in ethyl acetate.
At 25 °C the solubilities are 12.6 g/kg and 77.0 g/kg, respectively.
At 40 °C the solubilities are 18.0 g/kg and 238 g/kg, respectively.
At 50 °C the solubilities are 25.2 g/kg and 872 g/kg, respectively.
Neotame is acidic and its 0.5 wt% solution has a pH of 5.80.

Manufacture of Neotame
Industrially neotame is made from 3,3-dimethylbutanal and aspartame via reductive amination.
They are dissolved in methanol, palladium on carbon catalyst is added, air is replaced with hydrogen and the reaction is carried out in room temperature under pressure for a few hours.
Catalyst is filtered out.
This can be aided with diatomaceous earth.
Methanol is distilled followed by addition of water.
The mixture is cooled for a few hours, neotame is isolated via centrifugation, washed with water and vacuum dried.
Neotame is milled to suitable size.

Computed Properties
Molecular Weight: 378.5
XLogP3: -0.1
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 12
Exact Mass: 378.21547206
Monoisotopic Mass: 378.21547206
Topological Polar Surface Area: 105 Å²
Heavy Atom Count: 27
Formal Charge: 0
Complexity: 495
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count   0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Discovery of Neotame
The old artificial sweeteners such as saccharin and aspartame were discovered accidentally many years ago. On the other hand, the relatively newer sweeteners were often discovered only after countless trials based on our knowledge on chemistry.
Following the success of aspartame in the market, there were calls for developing a novel sweetener possessing additional qualities, i.e. higher heat stability, less restrictions on use, higher sweetness potency (less amount to achieve the same sweetness at a lower cost).
As such, thousands of compounds were being synthesised based on the simple structure of aspartame.
Among these compounds, neotame came up with the desirable qualities.

Description of Neotame
Catalogue Number: 107071

Product Information of Neotame
CAS number: 165450-17-9
Molar Mass: 378.46 g/mol
HS Code: 2924 29 70
Quality Level: MQ500
Safety Information according to GHS
Storage class: 10 - 13 Other liquids and solids
WGK: WGK 3 highly hazardous to water
Storage and Shipping Information
Storage Store at +15°C to +25°C.

Description of Neotame
Neotame is a high-intensity sweetener that is about 7,000 times sweeter than sugar.
It has been shown to be safe for use in foods and beverages by the United States Food and Drug Administration (USFDA).
Neotame has been used to treat wastewater in the treatment of toxic chemicals such as caproic acid.
The water vapor from neotame's reaction with phosphorus pentoxide may be analyzed using an analytical method.
Neotame is not metabolized by the body and does not contain calories.
Neotame is made up of aspartame, phenylalanine, and methanol.

CAS Number:165450-17-9
Molecular Weight:378.46
Beilstein:8352678
MDL number:MFCD09039056
PubChem Substance ID:329757524
E Number: E961

Physical Properties of Neotame:
Appearance: white powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 81.00 to 84.00 °C. @ 760.00 mm Hg
Boiling Point: 565.27 °C. @ 760.00 mm Hg (est)
Flash Point: 564.00 °F. TCC ( 295.70 °C. ) (est)
logP (o/w): 3.834 (est)
Soluble in:alcohol
water, 14.4 mg/L @ 25 °C (est)
Insoluble in: water

How is Neotamemade?
Generally, neotame is produced by the reaction between aspartame and 3,3-dimethylbutyraldehyde under hydrogen pressure.
Other raw materials involved in the reactions are methanol (solvent), palladium/carbon (catalyst), and diatomaceous earth (food grade may be used as a filtering aid).

Specification of Neotame
CAS number: 165450-17-9
Chemical formula: C20H30N2O5
Molecular Weight: 378.47

Properties of Neotame
Appearance: A white, crystalline powder or granular with a clean, sweet taste.

Neotame's name comes from its molecular structure, a 6-carbon neohexyl group attached to the amine nitrogen of aspartame.

Solubility of Neotame
Sparingly soluble in water (solubility in water, 12.6g/L at 25℃, aspartame is 10g/L) and very soluble in alcohol.

Neotame (INS 961, E 961) is an amino acid-based low calorie sweetener.
The amino acids in neotame are found naturally in most protein-containing foods, including meats, dairy products and vegetables.
Neotame is approximately 8000 times sweeter than sucrose.
Neotame is readily absorbed and completely eliminated, not contributing calories.
Extensive studies confirm the safety of neotame for use as a sweetener and flavour enhancer.
Neotame was evaluated and given a positive safety assessment by JECFA (Joint FAO/WHO Expert Committee on Food Additives) in 2003 and by the EFSA (European Food Safety Authority) in 2007.
The Acceptable Daily Intake (ADI) for neotame has been set at 0-2 mg/kg body weight by both JECFA and EFSA.

Description of Neotame
Neotame is a derivative of Aspartame and is a low-caloric and high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar.
Neotame is a non-nutritive sweetener and flavor enhancer that can be used in a variety of foods.

Molecular Weight: 378.46
Formula: C20H30N2O5
CAS No.: 165450-17-9
SMILES: COC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NCCC(C)(C)C)=O)=O

Storage
Powder: -20°C 3 years

Title: Neotame
CAS Registry Number: 165450-17-9
CAS Name: N-(3,3-Dimethylbutyl)-L-a-aspartyl-L-phenylalanine 2-methyl ester
Additional Names: N-[N-(3,3-Dimethylbutyl)-L-a-aspartyl]-L-phenylalanine 1-methyl ester
Molecular Formula: C20H30N2O5
Molecular Weight: 378.46
Percent Composition: C 63.47%, H 7.99%, N 7.40%, O 21.14%
Properties: Occurs as the monohydrate.
White crystalline powder from ethyl acetate/hexane, mp 80-83°; also reported as mp 80.9-83.4° from aq MeOH.
Melting point: mp 80-83°; mp 80.9-83.4° from aq MeOH
pKa: pKa1 3.01; pKa2 8.02

Use: Non-nutritive sweetener.

CAS No.165450-17-9
Chemical Name:Neotame
CBNumber:CB7500392
Molecular Formula:C20H30N2O5
Molecular Weight:378.46
MDL Number:MFCD09039056
MOL File:165450-17-9.mol
MSDS File:SDS
Modify Date:2022-08-26 12:13:31

Product description
Neotame is an artificial high intense sweetener that is between 7,000 and 13,000 times sweeter than sucrose (table sugar).
In the European Union, it is known by the E number E961.
Neotame is moderately heat-stable, extremely potent, rapidly metabolized, completely eliminated, and does not appear to accumulate in the body.

Specifications
CAS: 165450-17-9
MDL Number: MFCD09039056
Formula Weight: 378.46
Percent Purity: ≥98.0% (HPLC)
Type: Analytical Standard
Linear Formula: C20H30N2O5
Synonym
N-[N-(3,3-Dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester
Physical Form: Neat
Grade: Analytical Standard

Description of Neotame
Neotame is an artificial sweetener made by NutraSweet that is between 7,000 and 13,000 times sweeter than sucrose.
Neotame is moderately heat stable and extremely potent.
Neotame is rapidly metabolized and completely eliminated and does not appear to accumulate in the body.
Neotame is chemically similar to the artificial sweetener aspartame but is used at vastly lower levels and is more stable.
Chemically, Neotame has a 3,3-dimethylbutyl group attached to the amino group of the aspartic acid portion of the molecule.
Peptidases, which would typically break the peptide bond between the aspartic acid and phenylalanine moieties, are effectively blocked by the presence of the 3,3-dimethylbutyl moiety, thus reducing the production of phenylalanine, thereby making its consumption by those who suffer from phenylketonuria safe.

Chemical Properties of Neotame
Appearance: White or off white crystalline powder
CAS Number: 165450-17-9
Density: 1.133 g/cm3
IUPAC Name: (3S)-3-(3,3-Dimethylbutylamino)-4-[[(2S)-1-Methoxy-1-oxo-3-Phenylpropan-2-yl]Amino]-4-Oxobutanoic Acid
Molar Mass: 378.46 g/mol
Molecular Formula: C20H30N2O5

TYPICAL PRODUCT SPECIFICATIONS
MOLECULAR WEIGHT: 378.46
EINECS: 253-404-6
INCHI: HLIAVLHNDJUHFG-HOTGVXAUSA-N

Neotame is a Derivative of the dipeptide composed of the amino acids, aspartic acid and phenylalanine Neotame uses and applications include: Flavor enhancer, sweetener, and masking agent in beverages, tabletop sweeteners, chewing gum, confectionery, baked goods, frozen desserts, ice cream, yogurt, cereal
Suggested storage of Neotame: 5 yrs.
when stored at ambient conditions; avoid high heat, humidity

Neotame is a sugar substitute that is 7,000 to 13,000 times sweeter than regular table sugar.
Like other artificial sweeteners, only a small amount of the substance is needed to be an effective flavor enhancer.
In fact, this is what makes neotame of great interest to manufacturers of food products, since Neotame is considerably less expensive to use as a sweetener than refined sugar or high fructose corn syrup.

Description of Neotame:
Neotame is a white to off white powder with a clean, sweet taste.
Neotame sparingly solubles in water and very soluble in alcohol and ethyl acetate.
The pH of a 0.5% solution is between 5 and 7.
Regulatory approval for Canada was received in 2007.

Features of Neotame:
Neotame Can be blended with nutritive sweeteners, including high fructose corn syrup and sucrose, as well as high intensity sweeteners, to match taste of existing products while providing significant cost savings.
Neotame Is a versatile food ingredient.
Neotame's properties make it an effective sweetener and flavour enhancer. Efficacy and potency will vary depending on the actual application in which Neotame is used.

Applications of Neotame:
Beverages, tabletop sweeteners, chewing gums, confections, baked goods, frozen desserts/ice cream, yogurt, dietary supplement and OTC pharmaceuticals.
Neotame has similar taste of Aspartame.
Neotame doesn’t produce bitter and other after-taste.
Neotame'S sweetness is 8000 to 10000 times sweeter than sucrose.

As a functional sweetener, Neotame is harmless to human beings and is helpful for adjustment and facilitation to human performance.
Neotame's sweetness tastes pure, fresh and natural but.
Compares to Aspartame, it is better in safety and cheaper in cost.
Neotame's nutritional factors are easy to be absorbed by human beings and facilitates the multiplication of bifidobacterium.
Neotame produces low energy or non-energy, suitable for diabetics and doesn’t cause tooth decay or change of blood sugar.
Neotame is the prior choice for health food.

Use
Canned fruit, jelly, soft drink, bakery food, chewing gum, table-top Sweeteners and etc.
Medicine, toothpaste, cosmetic, cigarette filter and etc.

Physico-chemical Properties of Neotame
Molecular Formula: C20H30N2O5
Molar Mass: 378.463
Density: 1.133g/cm3
Boling Point: 565.3°C at 760 mmHg
Flash Point: 295.7°C
Vapor Presure: 1.29E-13mmHg at 25°C
Refractive Index: 1.521
Use: Sweeteners

CAS #: 165450-17-9
Formula: C20H30N2O5

Applications of Neotame
Beverages, fruit juices, tabletop sweetener, protein powder, dairy products, chewing gum, toothpaste, desserts, sauces, baked goods

Description
Neotame is an artificial sweetener and aspartame derivative that is 8,000 times as sweet as sucrose.
Unlike aspartame, neotame is not metabolized to phenylalanine and so does not require labeling for individuals with PKU.
Neotame is commonly blended with other artificial sweeteners to for synergistic effects.
Neotame's stability at high temperatures allow neotame to be used in baking application where aspartame would be unsuitable.

Chemical Taxonomy
Description: Belongs to the class of organic compounds known as peptides.
Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
Kingdom Organic compounds
Super Class: Organic acids and derivatives
Class: Carboxylic acids and derivatives
Sub Class: Amino acids, peptides, and analogues
Direct Parent: Peptides

Alternative Parents of Neotame
Phenylalanine and derivatives
Aspartic acid and derivatives
Alpha amino acid esters
N-acyl-alpha amino acids and derivatives
Alpha amino acid amides
Amphetamines and derivatives
Fatty acid esters
N-acyl amines
Dicarboxylic acids and derivatives
Methyl esters
Secondary carboxylic acid amides
Amino acids
Dialkylamines
Carboxylic acids
Hydrocarbon derivatives
Carbonyl compounds
Organic oxides
Organopnictogen compounds
Substituents
Alpha peptide
Phenylalanine or derivatives
Aspartic acid or derivatives
Alpha-amino acid ester
N-acyl-alpha amino acid or derivatives
Alpha-amino acid amide
N-substituted-alpha-amino acid
Alpha-amino acid or derivatives
Amphetamine or derivatives
Fatty acid ester
Monocyclic benzene moiety
Dicarboxylic acid or derivatives
Fatty amide
N-acyl-amine
Fatty acyl
Benzenoid
Methyl ester
Secondary carboxylic acid amide
Amino acid or derivatives
Amino acid
Carboxylic acid ester
Carboxamide group
Secondary amine
Secondary aliphatic amine
Carboxylic acid
Amine
Carbonyl group
Organic nitrogen compound
Organic oxygen compound
Organonitrogen compound
Organooxygen compound
Hydrocarbon derivative
Organopnictogen compound
Organic oxide
Aromatic homomonocyclic compound
Molecular Framework Aromatic homomonocyclic compounds

What Is Neotame E961?
Neotame E961 is a white powdered no-calorie sweetener, which is a derivative of the dipeptide composed of the amino acids, aspartic acid and phenylalanine.
The components of neotame are joined together to form a uniquely sweet ingredient.
The FDA approved the use of neotame as a general purpose sweetener in July 2002.
Neotame E961 is used in the application of canned fruit, jellies, soft drinks, bakery food, and chewing gum.

Possible Side Effects of Neotame E961
Neotame is generally considered a safe ingredient. Possible long-term side effects
brain damage
bodily tissue damage

Neotame sweetener Application
Neotame is a non-nutritive, non-energy sweetener.
Neotame has high sweetness, no toxic side effects and its sweetness cost is much lower than that of sucrose and aspartame, so Neotame can be widely used in the production of food industry.
Currently, neotame has been approved by more than 100 countries for use in more than 1000 kinds of products.

Benefits of Neotame:
It has zero calories per serving and zero glycemic index.
This makes it suitable as part of a diabetic diet.
Unlike aspartame Neotame is safe for people with the Phenylketonuria (PKU) disorder.

Application of Neotame
Carbonated drinks and still beverages;
Jams, jelly, milk prodcts, syrup,confections
Baked goods, desserts
Ice cream, cake, udding, wine, fruit can, etc.

Neotame is by far the world's most sweet synthetic sweeteners , is the world 's safest , closest taste of sucrose sweetener.
The Chinese Ministry of Health approved neotame as a sweetener commonly used in a variety of foods and beverages , dosage according to production needs, neotame is the only safest sweetener agent with no limit to use in the food approved the Ministry of Health.
Numerous studies indicate that neotame useful in including children , pregnant women , lactating women and patients with diabetes , including all groups. Neotame without using special show for PKU patients , neotame sweetener is currently the only artificial sweeteners without contraindications for human being.
Neotame in the human body 's metabolism quickly .
The main metabolic pathway enzymes produced by the body to make methyl ester hydrolysis , and finally generate skimmed neotame and methanol.
Neotame in the body produced by the decomposition of methanol far from sufficient to constitute a health hazard to humans .
Compared with ordinary food fruit juice, vegetables and vegetable juices, neotame decomposition generates minimal amount of methanol.
For example , tomato juice containing neotame methanol beverages containing more than 200 times.
Neotame can be thorough with urine and feces excreted not accumulate in the human body.
Neotame provide more convenient for food and beverage manufacturers to develop new products, because Neotame can be used alone , but also with other nutritional or non -nutritive sweetener mix .
Neotame provide a more flexible solution of sweetness for food manufacturers.
Adding in starchy foods can inhibit the aging of starch , extend shelf life of food ; in eggs , fish and other protein-rich foods to add it inhibits protein denaturation, keep food good taste.

Neotame in the dry state, finished in powder form has excellent stability , for example, a mixture of powdered beverages and desserts.
In the dry and proper storage conditions, it can be stored for at least five years.
Because neotame is not hygroscopic , low energy and is very suitable as a table-top sweeteners .
The study shows that neotame sweetness as table can store at least 156 weeks .

What is Neotame?
Neotame is a non-caloric artificial sweetener derived from Aspartame with a characteristic liquorice taste.
Neotame is used to substitute sucrose in low calorie products.
Neotame is 7,000 – 13,000 times sweeter than sucrose, and 30 – 60 times sweeter than aspartame.

Benefits of neotame include:
High heat and pH stability compared to Aspartame which allows its usage in baking
Leaves no aftertaste
Safe for people with phenylketonuria
Provides slower sweetness onset and lingering sweetness compared to sucrose and aspartame

Function OF Neotame
Compared to other non-caloric sweeteners, Neotame provides a similar taste profile to sucrose at lower concentrations in baked goods.
Neotame provides a clean taste and no residual metallic off-flavors.

Nutrition OF Neotame
Because Neotame cannot be metabolized by humans, Neotame is a non caloric sweetener.
The Acceptable Daily Intake (ADI) of Neotame is 0.02 mg/kg.1,2
This is safe for individuals with phenylketonuria and is considered a non cariogenic sweetener with no impact on glycaemic control.

Commercial production
Neotame is commercially produced from aspartame using the following process.

Reaction: aspartame and 3,3-methylbutyraldehyde are reacted with hydrogen gas in methanol.
Distillation: the obtained solution is distilled to remove the remaining methanol.
Washing with water (2.5 liter per aspartame mole) followed by cooling.
Isolation: centrifugation isolates the portion.
Washing to remove impurities.
Drying: using a vacuum drier to obtain a crystalline powder.
Sieving: to the appropriate granulometry.
Packaging
Application
Neotame is commonly used in low calorie food products such as:

Carbonated beverages
Dressings and fillings
Baked goods
Chewing gums
Sauces
This sweetener is stable under baking pH, moisture and temperature conditions.
Neotame is not synergetic with other alternative sweeteners, except with saccharin at a 14-25% rate.
The characteristic licorice flavor is usually reduced by blending with other intense sweeteners.

Other considerations when using neotame:
Potential flavor modification, thus the need for reducing the level of certain flavors such as vanilla, mint and cinnamon in confections.
The low concentration in baking formulas may require adding a bulking agent to compensate for sucrose elimination.

Neotame (E961) is a white to off-white powder with a sweet taste.
E961 is the derivative of the dipeptide composed of the amino acids, aspartic acid and phenylalanine.
Neotame E961 is approximately 8000 times sweeter than sugar on a weight basis.
Sinofi is a reliable E961 Neotame supplier in China.
We can supply this ingredient at a competitive Neotame price.

E No.:   E961
Synonym: Neotame
CAS No.: 165450-17-9
Formula   C20H30N2O5
Packaging: 1Kg/Bag, 25Kg/Drum
QC: HACCP, Kosher, Halal, Iso
Similar to NutraSweet
Origin:   China
Neotame Sweetener Uses:
Sugar Substitutes
Chewing Gum
Dairy Products
Confections
Baking Food
Yogurt
Frozen Desserts
Soft Drink
Beverage Powder
Instant Coffee
Chai Tea
Puddings
Ice Cream, Cereal
Feed
Flavor Enhancer
pharmaceutical.

Neotame Sweetener Specification:
Appearance: white to off-white powder
Assay (Dry basis): 97% -102%
Specific Rotation: -40.0o – 43.4o
Moisture: ≤5.0%
pH: 5.0-7.0
Related substances: ≤2.0%
Residue on ignitio: ≤0.1%
Lead: ≤2.0 mg/Kg
Ethanol Solubility: 100g/100g
Total Aerobic Bacteria ≤250cfu/g
Fungi: ≤100cfu/g
Coliform: ≤10mpn/g

Synonyms of Neotame
Neotame
165450-17-9
(S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid
UNII-VJ597D52EX
VJ597D52EX
NC 00723
HSDB 7965
(S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic ac
Neotame [NF]
L-Phenylalanine, N-(3,3-dimethylbutyl)-L-alpha-aspartyl-, 2-methyl ester
(3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
N-(N-(3,3-dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl ester
MFCD09039056
SCHEMBL4311
Neotame, analytical standard
NEOTAME (200 MG)
CHEMBL3718532
CHEBI:8350
DTXSID50167950
Neotame 1000 microg/mL in Water
methyl N-(3,3-dimethylbutyl)-L-alpha-aspartyl-L-phenylalaninate
s4442
ZINC33965935
AKOS016842430
AM8456
BCP9000982
CS-W011769
GS-3213
HY-W011053
(3S)-3-[(3,3-dimethylbutyl)amino]-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
NC-00723
BCP0726000005N1112
450N179
A810640
Q415698
J-010204
N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine methyl ester
(3S)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-(3,3-dimethylbutylamino)-4-oxo-butanoic acid
(S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoicacid